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Overview

Uniprot ID	Q9H8H2
Protein Name	ATP-dependent DNA helicase DDX31
Gene Name	DDX31
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
138	QAKATKRKYQASSEA
172	KETQRTFKGNAQKMF

Function

May have DNA helicase activity and RNA helicase activity. Probably have ssDNA and RNA dependent ATPase activity (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed:23019224)

Protein Sequence

10 MAPDLASQRH 20 SESFPSVNSR 30 PNVILPGREG 40 RREGLPPGGG 50 TRGSLVPTRP 60 VPPSPAPLGT 70 SPYSWSRSGP 80 GRGGGAGSSR 90 VPRGVPGPAV 100 CAPGSLLHHA 110 SPTQTMAAAD 120 GSLFDNPRTF 130 SRRPPAQASR 140 QAKATKRKYQ 150 ASSEAPPAKR 160 RNETSFLPAK 170 KTSVKETQRT 180 FKGNAQKMFS 190 PKKHSVSTSD 200 RNQEERQCIK 210 TSSLFKNNPD 220 IPELHRPVVK 230 QVQEKVFTSA 240 AFHELGLHPH 250 LISTINTVLK 260 MSSMTSVQKQ 270 SIPVLLEGRD 280 ALVRSQTGSG 290 KTLAYCIPVV 300 QSLQAMESKI 310 QRSDGPYALV 320 LVPTRELALQ 330 SFDTVQKLLK 340 PFTWIVPGVL 350 MGGEKRKSEK 360 ARLRKGINIL 370 ISTPGRLVDH 380 IKSTKNIHFS 390 RLRWLVFDEA 400 DRILDLGFEK 410 DITVILNAVN 420 AECQKRQNVL 430 LSATLTEGVT 440 RLADISLHDP 450 VSISVLDKSH 460 DQLNPKDKAV 470 QEVCPPPAGD 480 KLDSFAIPES 490 LKQHVTVVPS 500 KLRLVCLAAF 510 ILQKCKFEED 520 QKMVVFFSSC 530 ELVEFHYSLF 540 LQTLLSSSGA 550 PASGQLPSAS 560 MRLKFLRLHG 570 GMEQEERTAV 580 FQEFSHSRRG 590 VLLCTDVAAR 600 GLDLPQVTWI 610 VQYNAPSSPA 620 EYIHRIGRTA 630 RIGCHGSSLL 640 ILAPSEAEYV 650 NSLASHKINV 660 SEIKMEDILC 670 VLTRDDCFKG 680 KRWGAQKSHA 690 VGPQEIRERA 700 TVLQTVFEDY 710 VHSSERRVSW 720 AKKALQSFIQ 730 AYATYPRELK 740 HIFHVRSLHL 750 GHVAKSFGLR 760 DAPRNLSALT 770 RKKRKAHVKR 780 PDLHKKTQSK 790 HSLAEILRSE 800 YSSGMEADIA 810 KVKKQNAPGE 820 PGGRPLQHSL 830 QPTPCFGRGK 840 TLKWRKTQKG 850 VQRDSKTSQK V

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003724	RNA helicase activity
Biological Process	GO:0042254	ribosome biogenesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.