Search Results

Overview

Uniprot IDQ9H8H3
Protein NameThiol S-methyltransferase TMT1A
Gene NameTMT1A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
109 NFEKFLIKSIAENRH
219 LERASFSKLKLQHIQ
221 RASFSKLKLQHIQAP
54 YNEQMASKKRELFSN

Function

Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358)

Protein Sequence

10 MELTIFILRL 20 AIYILTFPLY 30 LLNFLGLWSW 40 ICKKWFPYFL 50 VRFTVIYNEQ 60 MASKKRELFS 70 NLQEFAGPSG 80 KLSLLEVGCG 90 TGANFKFYPP 100 GCRVTCIDPN 110 PNFEKFLIKS 120 IAENRHLQFE 130 RFVVAAGENM 140 HQVADGSVDV 150 VVCTLVLCSV 160 KNQERILREV 170 CRVLRPGGAF 180 YFMEHVAAEC 190 STWNYFWQQV 200 LDPAWHLLFD 210 GCNLTRESWK 220 ALERASFSKL 230 KLQHIQAPLS 240 WELVRPHIYG YAVK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005811 lipid droplet
Cellular Component GO:0016020 membrane
Cellular Component GO:1904724 tertiary granule lumen
Molecular Function GO:0008168 methyltransferase activity
Molecular Function GO:0001734 mRNA m(6)A methyltransferase activity
Molecular Function GO:0008173 RNA methyltransferase activity
Molecular Function GO:0018708 thiol S-methyltransferase activity
Biological Process GO:0180035 lncRNA processing
Biological Process GO:0032259 methylation
Biological Process GO:0042476 odontogenesis
Biological Process GO:0001649 osteoblast differentiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.