Search Results
Overview
| Uniprot ID | Q9H8L6 |
|---|---|
| Protein Name | Multimerin-2 |
| Gene Name | MMRN2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 73 | VTLLALCKTEKFLIH |
Function
Extracellular matrix protein (PubMed:22020326, PubMed:28671670, PubMed:28912033). Affects several essential steps in angiogenesis including endothelial cell proliferation, migration, and tube formation (PubMed:22020326, PubMed:28671670, PubMed:28912033). Positively regulates angiogenesis by acting as a ligand for CD93 receptor (PubMed:28671670, PubMed:28912033)
Protein Sequence
10
MILSLLFSLG
20
GPLGWGLLGA
30
WAQASSTSLS
40
DLQSSRTPGV
50
WKAEAEDTGK
60
DPVGRNWCPY
70
PMSKLVTLLA
80
LCKTEKFLIH
90
SQQPCPQGAP
100
DCQKVKVMYR
110
MAHKPVYQVK
120
QKVLTSLAWR
130
CCPGYTGPNC
140
EHHDSMAIPE
150
PADPGDSHQE
160
PQDGPVSFKP
170
GHLAAVINEV
180
EVQQEQQEHL
190
LGDLQNDVHR
200
VADSLPGLWK
210
ALPGNLTAAV
220
MEANQTGHEF
230
PDRSLEQVLL
240
PHVDTFLQVH
250
FSPIWRSFNQ
260
SLHSLTQAIR
270
NLSLDVEANR
280
QAISRVQDSA
290
VARADFQELG
300
AKFEAKVQEN
310
TQRVGQLRQD
320
VEDRLHAQHF
330
TLHRSISELQ
340
ADVDTKLKRL
350
HKAQEAPGTN
360
GSLVLATPGA
370
GARPEPDSLQ
380
ARLGQLQRNL
390
SELHMTTARR
400
EEELQYTLED
410
MRATLTRHVD
420
EIKELYSESD
430
ETFDQISKVE
440
RQVEELQVNH
450
TALRELRVIL
460
MEKSLIMEEN
470
KEEVERQLLE
480
LNLTLQHLQG
490
GHADLIKYVK
500
DCNCQKLYLD
510
LDVIREGQRD
520
ATRALEETQV
530
SLDERRQLDG
540
SSLQALQNAV
550
DAVSLAVDAH
560
KAEGERARAA
570
TSRLRSQVQA
580
LDDEVGALKA
590
AAAEARHEVR
600
QLHSAFAALL
610
EDALRHEAVL
620
AALFGEEVLE
630
EMSEQTPGPL
640
PLSYEQIRVA
650
LQDAASGLQE
660
QALGWDELAA
670
RVTALEQASE
680
PPRPAEHLEP
690
SHDAGREEAA
700
TTALAGLARE
710
LQSLSNDVKN
720
VGRCCEAEAG
730
AGAASLNASL
740
HGLHNALFAT
750
QRSLEQHQRL
760
FHSLFGNFQG
770
LMEANVSLDL
780
GKLQTMLSRK
790
GKKQQKDLEA
800
PRKRDKKEAE
810
PLVDIRVTGP
820
VPGALGAALW
830
EAGSPVAFYA
840
SFSEGTAALQ
850
TVKFNTTYIN
860
IGSSYFPEHG
870
YFRAPERGVY
880
LFAVSVEFGP
890
GPGTGQLVFG
900
GHHRTPVCTT
910
GQGSGSTATV
920
FAMAELQKGE
930
RVWFELTQGS
940
ITKRSLSGTA
FGGFLMFKT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0002042 | cell migration involved in sprouting angiogenesis |
| Biological Process | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway |
| Biological Process | GO:1900426 | positive regulation of defense response to bacterium |
| Biological Process | GO:1905278 | positive regulation of epithelial tube formation |
| Biological Process | GO:1905332 | positive regulation of morphogenesis of an epithelium |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.