Search Results

Overview

Uniprot ID	Q9H8M2
Protein Name	Bromodomain-containing protein 9
Gene Name	BRD9
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
29	KPLEKPLKLVLKVGG
468	QRRNVPMKPPDEAKV

Function

Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312)

Protein Sequence

10 MGKKHKKHKA 20 EWRSSYEDYA 30 DKPLEKPLKL 40 VLKVGGSEVT 50 ELSGSGHDSS 60 YYDDRSDHER 70 ERHKEKKKKK 80 KKKSEKEKHL 90 DDEERRKRKE 100 EKKRKREREH 110 CDTEGEADDF 120 DPGKKVEVEP 130 PPDRPVRACR 140 TQPAENESTP 150 IQQLLEHFLR 160 QLQRKDPHGF 170 FAFPVTDAIA 180 PGYSMIIKHP 190 MDFGTMKDKI 200 VANEYKSVTE 210 FKADFKLMCD 220 NAMTYNRPDT 230 VYYKLAKKIL 240 HAGFKMMSKQ 250 AALLGNEDTA 260 VEEPVPEVVP 270 VQVETAKKSK 280 KPSREVISCM 290 FEPEGNACSL 300 TDSTAEEHVL 310 ALVEHAADEA 320 RDRINRFLPG 330 GKMGYLKRNG 340 DGSLLYSVVN 350 TAEPDADEEE 360 THPVDLSSLS 370 SKLLPGFTTL 380 GFKDERRNKV 390 TFLSSATTAL 400 SMQNNSVFGD 410 LKSDEMELLY 420 SAYGDETGVQ 430 CALSLQEFVK 440 DAGSYSKKVV 450 DDLLDQITGG 460 DHSRTLFQLK 470 QRRNVPMKPP 480 DEAKVGDTLG 490 DSSSSVLEFM 500 SMKSYPDVSV 510 DISMLSSLGK 520 VKKELDPDDS 530 HLNLDETTKL 540 LQDLHEAQAE 550 RGGSRPSSNL 560 SSLSNASERD 570 QHHLGSPSRL 580 SVGEQPDVTH 590 DPYEFLQSPE PAASAKT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0035861	site of double-strand break
Cellular Component	GO:0016514	SWI/SNF complex
Molecular Function	GO:0140566	histone reader activity
Molecular Function	GO:0003676	nucleic acid binding
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0000724	double-strand break repair via homologous recombination
Biological Process	GO:0045596	negative regulation of cell differentiation
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:1902459	positive regulation of stem cell population maintenance
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.