Search Results

Overview

Uniprot ID	Q9H8M5
Protein Name	Metal transporter CNNM2
Gene Name	CNNM2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
617	KQTDSEMKVKISPQL

Function

Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity)

Protein Sequence

10 MIGCGACEPK 20 VKMAGGQAAA 30 ALPTWKMAAR 40 RSLSARGRGI 50 LQAAAGRLLP 60 LLLLSCCCGA 70 GGCAAVGENE 80 ETVIIGLRLE 90 DTNDVSFMEG 100 GALRVSERTR 110 VKLRVYGQNI 120 NNETWSRIAF 130 TEHERRRHSP 140 GERGLGGPAP 150 PEPDSGPQRC 160 GIRTSDIIIL 170 PHIILNRRTS 180 GIIEIEIKPL 190 RKMEKSKSYY 200 LCTSLSTPAL 210 GAGGSGSTGG 220 AVGGKGGSGV 230 AGLPPPPWAE 240 TTWIYHDGED 250 TKMIVGEEKK 260 FLLPFWLQVI 270 FISLLLCLSG 280 MFSGLNLGLM 290 ALDPMELRIV 300 QNCGTEKEKN 310 YAKRIEPVRR 320 QGNYLLCSLL 330 LGNVLVNTTL 340 TILLDDIAGS 350 GLVAVVVSTI 360 GIVIFGEIVP 370 QAICSRHGLA 380 VGANTIFLTK 390 FFMMMTFPAS 400 YPVSKLLDCV 410 LGQEIGTVYN 420 REKLLEMLRV 430 TDPYNDLVKE 440 ELNIIQGALE 450 LRTKTVEDVM 460 TPLRDCFMIT 470 GEAILDFNTM 480 SEIMESGYTR 490 IPVFEGERSN 500 IVDLLFVKDL 510 AFVDPDDCTP 520 LKTITKFYNH 530 PLHFVFNDTK 540 LDAMLEEFKK 550 GKSHLAIVQR 560 VNNEGEGDPF 570 YEVLGIVTLE 580 DVIEEIIKSE 590 ILDETDLYTD 600 NRTKKKVAHR 610 ERKQDFSAFK 620 QTDSEMKVKI 630 SPQLLLAMHR 640 FLATEVEAFS 650 PSQMSEKILL 660 RLLKHPNVIQ 670 ELKYDEKNKK 680 APEYYLYQRN 690 KPVDYFVLIL 700 QGKVEVEAGK 710 EGMKFEASAF 720 SYYGVMALTA 730 SPVPLSLSRT 740 FVVSRTELLA 750 AGSPGENKSP 760 PRPCGLNHSD 770 SLSRSDRIDA 780 VTPTLGSSNN 790 QLNSSLLQVY 800 IPDYSVRALS 810 DLQFVKISRQ 820 QYQNALMASR 830 MDKTPQSSDS 840 ENTKIELTLT 850 ELHDGLPDET 860 ANLLNEQNCV 870 THSKANHSLH NEGAI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016323	basolateral plasma membrane
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0015095	magnesium ion transmembrane transporter activity
Biological Process	GO:0010960	magnesium ion homeostasis

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.