Overview
| Uniprot ID | Q9H8S9 |
|---|
| Protein Name | MOB kinase activator 1A |
|---|
| Gene Name | MOB1A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 104 |
WADGTNIKKPIKCSA |
| 11 |
LFSSRSSKTFKPKKN |
| 17 |
SKTFKPKKNIPEGSH |
Function
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38
Protein Sequence
10
MSFLFSSRSS
20
KTFKPKKNIP
30
EGSHQYELLK
40
HAEATLGSGN
50
LRQAVMLPEG
60
EDLNEWIAVN
70
TVDFFNQINM
80
LYGTITEFCT
90
EASCPVMSAG
100
PRYEYHWADG
110
TNIKKPIKCS
120
APKYIDYLMT
130
WVQDQLDDET
140
LFPSKIGVPF
150
PKNFMSVAKT
160
ILKRLFRVYA
170
HIYHQHFDSV
180
MQLQEEAHLN
190
TSFKHFIFFV
200
QEFNLIDRRE
210
LAPLQELIEK
LGSKDR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0030295 |
protein kinase activator activity |
| Molecular Function |
GO:0043539 |
protein serine/threonine kinase activator activity |
| Biological Process |
GO:0035329 |
hippo signaling |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.