Search Results

Overview

Uniprot IDQ9H8V3
Protein NameProtein ECT2
Gene NameECT2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
245 MKPEWIYKAWERRNE
441 KSCTKSSKSSTPVPS
845 TRAFSFSKTPKRALR

Function

Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death

Protein Sequence

10 MAENSVLTST 20 TGRTSLADSS 30 IFDSKVTEIS 40 KENLLIGSTS 50 YVEEEMPQIE 60 TRVILVQEAG 70 KQEELIKALK 80 TIKIMEVPVI 90 KIKESCPGKS 100 DEKLIKSVIN 110 MDIKVGFVKM 120 ESVEEFEGLD 130 SPEFENVFVV 140 TDFQDSVFND 150 LYKADCRVIG 160 PPVVLNCSQK 170 GEPLPFSCRP 180 LYCTSMMNLV 190 LCFTGFRKKE 200 ELVRLVTLVH 210 HMGGVIRKDF 220 NSKVTHLVAN 230 CTQGEKFRVA 240 VSLGTPIMKP 250 EWIYKAWERR 260 NEQDFYAAVD 270 DFRNEFKVPP 280 FQDCILSFLG 290 FSDEEKTNME 300 EMTEMQGGKY 310 LPLGDERCTH 320 LVVEENIVKD 330 LPFEPSKKLY 340 VVKQEWFWGS 350 IQMDARAGET 360 MYLYEKANTP 370 ELKKSVSMLS 380 LNTPNSNRKR 390 RRLKETLAQL 400 SRETDVSPFP 410 PRKRPSAEHS 420 LSIGSLLDIS 430 NTPESSINYG 440 DTPKSCTKSS 450 KSSTPVPSKQ 460 SARWQVAKEL 470 YQTESNYVNI 480 LATIIQLFQV 490 PLEEEGQRGG 500 PILAPEEIKT 510 IFGSIPDIFD 520 VHTKIKDDLE 530 DLIVNWDESK 540 SIGDIFLKYS 550 KDLVKTYPPF 560 VNFFEMSKET 570 IIKCEKQKPR 580 FHAFLKINQA 590 KPECGRQSLV 600 ELLIRPVQRL 610 PSVALLLNDL 620 KKHTADENPD 630 KSTLEKAIGS 640 LKEVMTHINE 650 DKRKTEAQKQ 660 IFDVVYEVDG 670 CPANLLSSHR 680 SLVQRVETIS 690 LGEHPCDRGE 700 QVTLFLFNDC 710 LEIARKRHKV 720 IGTFRSPHGQ 730 TRPPASLKHI 740 HLMPLSQIKK 750 VLDIRETEDC 760 HNAFALLVRP 770 PTEQANVLLS 780 FQMTSDELPK 790 ENWLKMLCRH 800 VANTICKADA 810 ENLIYTADPE 820 SFEVNTKDMD 830 STLSRASRAI 840 KKTSKKVTRA 850 FSFSKTPKRA 860 LRRALMTSHG 870 SVEGRSPSSN 880 DKHVMSRLSS 890 TSSLAGIPSP 900 SLVSLPSFFE 910 RRSHTLSRST THLI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005923 bicellular tight junction
Biological Process GO:0051988 regulation of attachment of spindle microtubules to kinetochore
Biological Process GO:2000431 regulation of cytokinesis, actomyosin contractile ring assembly
Biological Process GO:0045859 regulation of protein kinase activity
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0097149 centralspindlin complex
Cellular Component GO:0005813 centrosome
Cellular Component GO:0032154 cleavage furrow
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030496 midbody
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0090630 activation of GTPase activity
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0070830 bicellular tight junction assembly
Biological Process GO:0030154 cell differentiation
Biological Process GO:0071277 cellular response to calcium ion
Biological Process GO:0070301 cellular response to hydrogen peroxide
Biological Process GO:0071479 cellular response to ionizing radiation
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0007399 nervous system development
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0043123 positive regulation of canonical NF-kappaB signal transduction
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:1903438 positive regulation of mitotic cytokinetic process
Biological Process GO:0045666 positive regulation of neuron differentiation
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0015031 protein transport

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.