Search Results

Overview

Uniprot IDQ9H910
Protein NameJupiter microtubule associated homolog 2
Gene NameJPT2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
128 EEPKSDLKAARSIPA
176 PRPRSHNKVLNPPGG
59 EEPQNIPKRTNPPGG
67 RTNPPGGKGSGIFDE
90 HLNPPGGKTSDIFGS

Function

Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062)

Protein Sequence

10 MFQVPDSEGG 20 RAGSRAMKPP 30 GGESSNLFGS 40 PEEATPSSRP 50 NRMASNIFGP 60 TEEPQNIPKR 70 TNPPGGKGSG 80 IFDESTPVQT 90 RQHLNPPGGK 100 TSDIFGSPVT 110 ATSRLAHPNK 120 PKDHVFLCEG 130 EEPKSDLKAA 140 RSIPAGAEPG 150 EKGSARKAGP 160 AKEQEPMPTV 170 DSHEPRLGPR 180 PRSHNKVLNP 190 PGGKSSISFY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Biological Process GO:0075509 endocytosis involved in viral entry into host cell
Biological Process GO:0050848 regulation of calcium-mediated signaling

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.