Search Results
Overview
| Uniprot ID | Q9H936 |
|---|---|
| Protein Name | Mitochondrial glutamate carrier 1 |
| Gene Name | SLC25A22 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 4 | ****MADKQISLPAK |
| 80 | LTLVTPEKAIKLAAN |
| 83 | VTPEKAIKLAANDFF |
Function
Mitochondrial glutamate/H(+) symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (PubMed:11897791). Plays a role in the control of glucose-stimulated insulin secretion (By similarity)
Protein Sequence
10
MADKQISLPA
20
KLINGGIAGL
30
IGVTCVFPID
40
LAKTRLQNQQ
50
NGQRVYTSMS
60
DCLIKTVRSE
70
GYFGMYRGAA
80
VNLTLVTPEK
90
AIKLAANDFF
100
RHQLSKDGQK
110
LTLLKEMLAG
120
CGAGTCQVIV
130
TTPMEMLKIQ
140
LQDAGRIAAQ
150
RKILAAQGQL
160
SAQGGAQPSV
170
EAPAAPRPTA
180
TQLTRDLLRS
190
RGIAGLYKGL
200
GATLLRDVPF
210
SVVYFPLFAN
220
LNQLGRPASE
230
EKSPFYVSFL
240
AGCVAGSAAA
250
VAVNPCDVVK
260
TRLQSLQRGV
270
NEDTYSGILD
280
CARKILRHEG
290
PSAFLKGAYC
300
RALVIAPLFG
310
IAQVVYFLGI
320
AESLLGLLQD
PQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005280 | amino acid:proton symporter activity |
| Molecular Function | GO:0015183 | L-aspartate transmembrane transporter activity |
| Molecular Function | GO:0005313 | L-glutamate transmembrane transporter activity |
| Biological Process | GO:0015810 | aspartate transmembrane transport |
| Biological Process | GO:0015813 | L-glutamate transmembrane transport |
| Biological Process | GO:0043490 | malate-aspartate shuttle |
| Biological Process | GO:0006836 | neurotransmitter transport |
| Biological Process | GO:0050796 | regulation of insulin secretion |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.