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Overview

Uniprot ID	Q9H993
Protein Name	Damage-control phosphatase 1
Gene Name	DCPH1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
242	NCKKTREKASATRVY
40	IDTLHRHKSEFFEKH

Function

Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (PubMed:32682077). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (PubMed:32682077). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (PubMed:25732820). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (PubMed:25732820)

Protein Sequence

10 MAVVPASLSG 20 QDVGSFAYLT 30 IKDRIPQILT 40 KVIDTLHRHK 50 SEFFEKHGEE 60 GVEAEKKAIS 70 LLSKLRNELQ 80 TDKPFIPLVE 90 KFVDTDIWNQ 100 YLEYQQSLLN 110 ESDGKSRWFY 120 SPWLLVECYM 130 YRRIHEAIIQ 140 SPPIDYFDVF 150 KESKEQNFYG 160 SQESIIALCT 170 HLQQLIRTIE 180 DLDENQLKDE 190 FFKLLQISLW 200 GNKCDLSLSG 210 GESSSQNTNV 220 LNSLEDLKPF 230 ILLNDMEHLW 240 SLLSNCKKTR 250 EKASATRVYI 260 VLDNSGFELV 270 TDLILADFLL 280 SSELATEVHF 290 YGKTIPWFVS 300 DTTIHDFNWL 310 IEQVKHSNHK 320 WMSKCGADWE 330 EYIKMGKWVY 340 HNHIFWTLPH 350 EYCAMPQVAP 360 DLYAELQKAH 370 LILFKGDLNY 380 RKLTGDRKWE 390 FSVPFHQALN 400 GFHPAPLCTI 410 RTLKAEIQVG 420 LQPGQGEQLL 430 ASEPSWWTTG 440 KYGIFQYDGP L

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0097023	fructose 6-phosphate aldolase activity
Molecular Function	GO:0103026	fructose-1-phosphatase activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0016791	phosphatase activity
Molecular Function	GO:0051998	protein carboxyl O-methyltransferase activity
Molecular Function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0032259	methylation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.