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Overview

Uniprot ID	Q9H9A7
Protein Name	RecQ-mediated genome instability protein 1
Gene Name	RMI1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
441	DSHSLNNKILNREVV
453	EVVNYVQKRNSQISN

Function

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability

Protein Sequence

10 MNVTSIALRA 20 ETWLLAAWHV 30 KVPPMWLEAC 40 INWIQEENNN 50 VNLSQAQMNK 60 QVFEQWLLTD 70 LRDLEHPLLP 80 DGILEIPKGE 90 LNGFYALQIN 100 SLVDVSQPAY 110 SQIQKLRGKN 120 TTNDLVTAEA 130 QVTPKPWEAK 140 PSRMLMLQLT 150 DGIVQIQGME 160 YQPIPILHSD 170 LPPGTKILIY 180 GNISFRLGVL 190 LLKPENVKVL 200 GGEVDALLEE 210 YAQEKVLARL 220 IGEPDLVVSV 230 IPNNSNENIP 240 RVTDVLDPAL 250 GPSDEELLAS 260 LDENDELTAN 270 NDTSSERCFT 280 TGSSSNTIPT 290 RQSSFEPEFV 300 ISPRPKEEPS 310 NLSIHVMDGE 320 LDDFSLEEAL 330 LLEETVQKEQ 340 METKELQPLT 350 FNRNADRSIE 360 RFSHNPNTTN 370 NFSLTCKNGN 380 NNWSEKNVSE 390 QMTNEDKSFG 400 CPSVRDQNRS 410 IFSVHCNVPL 420 AHDFTNKEKN 430 LETDNKIKQT 440 SSSDSHSLNN 450 KILNREVVNY 460 VQKRNSQISN 470 ENDCNLQSCS 480 LRSSENSINL 490 SIAMDLYSPP 500 FVYLSVLMAS 510 KPKEVTTVKV 520 KAFIVTLTGN 530 LSSSGGIWSI 540 TAKVSDGTAY 550 LDVDFVDEIL 560 TSLIGFSVPE 570 MKQSKKDPLQ 580 YQKFLEGLQK 590 CQRDLIDLCC 600 LMTISFNPSL 610 SKAMVLALQD 620 VNMEHLENLK KRLNK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0031422	RecQ family helicase-topoisomerase III complex
Molecular Function	GO:0000166	nucleotide binding
Biological Process	GO:0006260	DNA replication
Biological Process	GO:0000724	double-strand break repair via homologous recombination
Biological Process	GO:0071139	resolution of DNA recombination intermediates
Biological Process	GO:0000712	resolution of meiotic recombination intermediates

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.