Search Results

Overview

Uniprot ID	Q9H9B4
Protein Name	Sideroflexin-1
Gene Name	SFXN1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
49	EQLESARKIVHDYRQ
72	ENELWRAKYIYDSAF

Function

Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). May also transport other amino acids including alanine and cysteine (PubMed:30442778)

Protein Sequence

10 MSGELPPNIN 20 IKEPRWDQST 30 FIGRANHFFT 40 VTDPRNILLT 50 NEQLESARKI 60 VHDYRQGIVP 70 PGLTENELWR 80 AKYIYDSAFH 90 PDTGEKMILI 100 GRMSAQVPMN 110 MTITGCMMTF 120 YRTTPAVLFW 130 QWINQSFNAV 140 VNYTNRSGDA 150 PLTVNELGTA 160 YVSATTGAVA 170 TALGLNALTK 180 HVSPLIGRFV 190 PFAAVAAANC 200 INIPLMRQRE 210 LKVGIPVTDE 220 NGNRLGESAN 230 AAKQAITQVV 240 VSRILMAAPG 250 MAIPPFIMNT 260 LEKKAFLKRF 270 PWMSAPIQVG 280 LVGFCLVFAT 290 PLCCALFPQK 300 SSMSVTSLEA 310 ELQAKIQESH 320 PELRRVYFNK GL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0015180	L-alanine transmembrane transporter activity
Molecular Function	GO:0015194	L-serine transmembrane transporter activity
Molecular Function	GO:0015075	monoatomic ion transmembrane transporter activity
Molecular Function	GO:0022857	transmembrane transporter activity
Biological Process	GO:0015808	L-alanine transport
Biological Process	GO:0015825	L-serine transport
Biological Process	GO:0006730	one-carbon metabolic process
Biological Process	GO:0140300	serine import into mitochondrion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.