Search Results
Overview
| Uniprot ID | Q9H9L3 |
|---|---|
| Protein Name | Interferon-stimulated 20 kDa exonuclease-like 2 |
| Gene Name | ISG20L2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | WLTPAPSKKADSVAA |
| 108 | LTPAPSKKADSVAAK |
| 153 | SKKNHPQKNAPQNST |
| 174 | KCSGASQKLPRKMVA |
| 79 | KTPSFPKKKTAASSN |
| 94 | GSGQPLDKKAAVSWL |
| 95 | SGQPLDKKAAVSWLT |
Function
3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group
Protein Sequence
10
MSTLLLNLDF
20
GEPPPKKALE
30
GNAKHRNFVK
40
KRRLLERRGF
50
LSKKNQPPSK
60
APKLHSEPSK
70
KGETPTVDGT
80
WKTPSFPKKK
90
TAASSNGSGQ
100
PLDKKAAVSW
110
LTPAPSKKAD
120
SVAAKVDLLG
130
EFQSALPKIN
140
SHPTRSQKKS
150
SQKKSSKKNH
160
PQKNAPQNST
170
QAHSENKCSG
180
ASQKLPRKMV
190
AIDCEMVGTG
200
PKGHVSSLAR
210
CSIVNYNGDV
220
LYDEYILPPC
230
HIVDYRTRWS
240
GIRKQHMVNA
250
TPFKIARGQI
260
LKILTGKIVV
270
GHAIHNDFKA
280
LQYFHPKSLT
290
RDTSHIPPLN
300
RKADCPENAT
310
MSLKHLTKKL
320
LNRDIQVGKS
330
GHSSVEDAQA
340
TMELYKLVEV
350
EWEEHLARNP
PTD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0000175 | 3'-5'-RNA exonuclease activity |
| Molecular Function | GO:0004527 | exonuclease activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006259 | DNA metabolic process |
| Biological Process | GO:0042254 | ribosome biogenesis |
| Biological Process | GO:0006396 | RNA processing |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.