Search Results

Overview

Uniprot ID	Q9H9Q2
Protein Name	COP9 signalosome complex subunit 7b
Gene Name	COPS7B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
257	TKKMSKVKGLVSSRH

Function

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

Protein Sequence

10 MAGEQKPSSN 20 LLEQFILLAK 30 GTSGSALTAL 40 ISQVLEAPGV 50 YVFGELLELA 60 NVQELAEGAN 70 AAYLQLLNLF 80 AYGTYPDYIA 90 NKESLPELST 100 AQQNKLKHLT 110 IVSLASRMKC 120 IPYSVLLKDL 130 EMRNLRELED 140 LIIEAVYTDI 150 IQGKLDQRNQ 160 LLEVDFCIGR 170 DIRKKDINNI 180 VKTLHEWCDG 190 CEAVLLGIEQ 200 QVLRANQYKE 210 NHNRTQQQVE 220 AEVTNIKKTL 230 KATASSSAQE 240 MEQQLAEREC 250 PPHAEQRQPT 260 KKMSKVKGLV SSRH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0008180	COP9 signalosome
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Biological Process	GO:0010387	COP9 signalosome assembly
Biological Process	GO:0000338	protein deneddylation
Biological Process	GO:2000434	regulation of protein neddylation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.