Search Results
Overview
| Uniprot ID | Q9HA47 |
|---|---|
| Protein Name | Uridine-cytidine kinase 1 |
| Gene Name | UCK1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 266 | PGMLTSGKRSHLESS |
Function
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702)
Protein Sequence
10
MASAGGEDCE
20
SPAPEADRPH
30
QRPFLIGVSG
40
GTASGKSTVC
50
EKIMELLGQN
60
EVEQRQRKVV
70
ILSQDRFYKV
80
LTAEQKAKAL
90
KGQYNFDHPD
100
AFDNDLMHRT
110
LKNIVEGKTV
120
EVPTYDFVTH
130
SRLPETTVVY
140
PADVVLFEGI
150
LVFYSQEIRD
160
MFHLRLFVDT
170
DSDVRLSRRV
180
LRDVRRGRDL
190
EQILTQYTTF
200
VKPAFEEFCL
210
PTKKYADVII
220
PRGVDNMVAI
230
NLIVQHIQDI
240
LNGDICKWHR
250
GGSNGRSYKR
260
TFSEPGDHPG
270
MLTSGKRSHL
ESSSRPH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0043771 | cytidine kinase activity |
| Molecular Function | GO:0004849 | uridine kinase activity |
| Biological Process | GO:0044211 | CTP salvage |
| Biological Process | GO:0044206 | UMP salvage |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.