Search Results

Overview

Uniprot ID	Q9HA64
Protein Name	Ketosamine-3-kinase
Gene Name	FN3KRP
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
123	KLGEMRLKEAGTVGR
45	VFVKVNPKAEARRMF

Function

Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively (PubMed:14633848, PubMed:15137908). Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:14633848, PubMed:15137908). Not able to phosphorylate fructoselysine (PubMed:14633848)

Protein Sequence

10 MEELLRRELG 20 CSSVRATGHS 30 GGGCISQGRS 40 YDTDQGRVFV 50 KVNPKAEARR 60 MFEGEMASLT 70 AILKTNTVKV 80 PKPIKVLDAP 90 GGGSVLVMEH 100 MDMRHLSSHA 110 AKLGAQLADL 120 HLDNKKLGEM 130 RLKEAGTVGR 140 GGGQEERPFV 150 ARFGFDVVTC 160 CGYLPQVNDW 170 QEDWVVFYAR 180 QRIQPQMDMV 190 EKESGDREAL 200 QLWSALQLKI 210 PDLFRDLEII 220 PALLHGDLWG 230 GNVAEDSSGP 240 VIFDPASFYG 250 HSEYELAIAG 260 MFGGFSSSFY 270 SAYHGKIPKA 280 PGFEKRLQLY 290 QLFHYLNHWN 300 HFGSGYRGSS LNIMRNLVK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016301	kinase activity
Molecular Function	GO:0102193	protein-ribulosamine 3-kinase activity
Biological Process	GO:0043687	post-translational protein modification

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.