Search Results
Overview
| Uniprot ID | Q9HA65 |
|---|---|
| Protein Name | TBC1 domain family member 17 |
| Gene Name | TBC1D17 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 133 | LKSIRRSKPGLSWAY |
Function
Probable RAB GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR) (PubMed:22854040). Involved in regulation of autophagy
Protein Sequence
10
MEGAGYRVVF
20
EKGGVYLHTS
30
AKKYQDRDSL
40
IAGVIRVVEK
50
DNDVLLHWAP
60
VEEAGDSTQI
70
LFSKKDSSGG
80
DSCASEEEPT
90
FDPGYEPDWA
100
VISTVRPQLC
110
HSEPTRGAEP
120
SCPQGSWAFS
130
VSLGELKSIR
140
RSKPGLSWAY
150
LVLVTQAGGS
160
LPALHFHRGG
170
TRALLRVLSR
180
YLLLASSPQD
190
SRLYLVFPHD
200
SSALSNSFHH
210
LQLFDQDSSN
220
VVSRFLQDPY
230
STTFSSFSRV
240
TNFFRGALQP
250
QPEGAASDLP
260
PPPDDEPEPG
270
FEVISCVELG
280
PRPTVERGPP
290
VTEEEWARHV
300
GPEGRLQQVP
310
ELKNRIFSGG
320
LSPSLRREAW
330
KFLLGYLSWE
340
GTAEEHKAHI
350
RKKTDEYFRM
360
KLQWKSVSPE
370
QERRNSLLHG
380
YRSLIERDVS
390
RTDRTNKFYE
400
GPENPGLGLL
410
NDILLTYCMY
420
HFDLGYVQGM
430
SDLLSPILYV
440
IQNEVDAFWC
450
FCGFMELVQG
460
NFEESQETMK
470
RQLGRLLLLL
480
RVLDPLLCDF
490
LDSQDSGSLC
500
FCFRWLLIWF
510
KREFPFPDVL
520
RLWEVLWTGL
530
PGPNLHLLVA
540
CAILDMERDT
550
LMLSGFGSNE
560
ILKHINELTM
570
KLSVEDVLTR
580
AEALHRQLTA
590
CPELPHNVQE
600
ILGLAPPAEP
610
HSPSPTASPL
620
PLSPTRAPPT
630
PPPSTDTAPQ
640
PDSSLEILPE
EEDEGADS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005776 | autophagosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0055037 | recycling endosome |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0042147 | retrograde transport, endosome to Golgi |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.