Search Results
Overview
| Uniprot ID | Q9HA77 |
|---|---|
| Protein Name | Probable cysteine--tRNA ligase, mitochondrial |
| Gene Name | CARS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 190 | GNAYSTAKGNVYFDL |
| 198 | GNVYFDLKSRGDKYG |
| 223 | GEPADSDKRHASDFA |
| 323 | EKMSKSLKNYITIKD |
| 382 | EDARAYMKGQLACGS |
| 407 | SSTKRAVKAALADDF |
| 439 | GQLRASLKEPEGPRS |
Function
Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys)
Protein Sequence
10
MLRTTRGPGL
20
GPPLLQAALG
30
LGRAGWHWPA
40
GRAASGGRGR
50
AWLQPTGRET
60
GVQVYNSLTG
70
RKEPLIVAHA
80
EAASWYSCGP
90
TVYDHAHLGH
100
ACSYVRFDII
110
RRILTKVFGC
120
SIVMVMGITD
130
VDDKIIKRAN
140
EMNISPASLA
150
SLYEEDFKQD
160
MAALKVLPPT
170
VYLRVTENIP
180
QIISFIEGII
190
ARGNAYSTAK
200
GNVYFDLKSR
210
GDKYGKLVGV
220
VPGPVGEPAD
230
SDKRHASDFA
240
LWKAAKPQEV
250
FWASPWGPGR
260
PGWHIECSAI
270
ASMVFGSQLD
280
IHSGGIDLAF
290
PHHENEIAQC
300
EVFHQCEQWG
310
NYFLHSGHLH
320
AKGKEEKMSK
330
SLKNYITIKD
340
FLKTFSPDVF
350
RFFCLRSSYR
360
SAIDYSDSAM
370
LQAQQLLLGL
380
GSFLEDARAY
390
MKGQLACGSV
400
REAMLWERLS
410
STKRAVKAAL
420
ADDFDTPRVV
430
DAILGLAHHG
440
NGQLRASLKE
450
PEGPRSPAVF
460
GAIISYFEQF
470
FETVGISLAN
480
QQYVSGDGSE
490
ATLHGVVDEL
500
VRFRQKVRQF
510
ALAMPEATGD
520
ARRQQLLERQ
530
PLLEACDTLR
540
RGLTAHGINI
550
KDRSSTTSTW
560
ELLDQRTKDQ
KSAG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004817 | cysteine-tRNA ligase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006423 | cysteinyl-tRNA aminoacylation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.