Search Results
Overview
| Uniprot ID | Q9HAB8 |
|---|---|
| Protein Name | Phosphopantothenate--cysteine ligase |
| Gene Name | PPCS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 46 | LVTSGGTKVPLEARP |
Function
Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11923312, PubMed:12906824, PubMed:29754768). Has a preference for ATP over CTP as a cosubstrate (PubMed:11923312)
Protein Sequence
10
MAEMDPVAEF
20
PQPPGAARWA
30
EVMARFAARL
40
GAQGRRVVLV
50
TSGGTKVPLE
60
ARPVRFLDNF
70
SSGRRGATSA
80
EAFLAAGYGV
90
LFLYRARSAF
100
PYAHRFPPQT
110
WLSALRPSGP
120
ALSGLLSLEA
130
EENALPGFAE
140
ALRSYQEAAA
150
AGTFLAVEFT
160
TLADYLHLLQ
170
AAAQALNPLG
180
PSAMFYLAAA
190
VSDFYVPVSE
200
MPEHKIQSSG
210
GPLQITMKMV
220
PKLLSPLVKD
230
WAPKAFIISF
240
KLETDPAIVI
250
NRARKALEIY
260
QHQVVVANIL
270
ESRQSFVFIV
280
TKDSETKLLL
290
SEEEIEKGVE
300
IEEKIVDNLQ
310
SRHTAFIGDR
N
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004632 | phosphopantothenate--cysteine ligase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006085 | acetyl-CoA biosynthetic process |
| Biological Process | GO:0015937 | coenzyme A biosynthetic process |
| Biological Process | GO:0003015 | heart process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.