Search Results

Overview

Uniprot ID	Q9HAD4
Protein Name	WD repeat-containing protein 41
Gene Name	WDR41
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
377	WGFGRVSKQASQPVK

Function

Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27103069, PubMed:27193190, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (PubMed:32303654). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292)

Protein Sequence

10 MLRWLIGGGR 20 EPQGLAEKSP 30 LQTIGEEQTQ 40 NPYTELLVLK 50 AHHDIVRFLV 60 QLDDYRFASA 70 GDDGIVVVWN 80 AQTGEKLLEL 90 NGHTQKITAI 100 ITFPSLESCE 110 EKNQLILTAS 120 ADRTVIVWDG 130 DTTRQVQRIS 140 CFQSTVKCLT 150 VLQRLDVWLS 160 GGNDLCVWNR 170 KLDLLCKTSH 180 LSDTGISALV 190 EIPKNCVVAA 200 VGKELIIFRL 210 VAPTEGSLEW 220 DILEVKRLLD 230 HQDNILSLIN 240 VNDLSFVTGS 250 HVGELIIWDA 260 LDWTMQAYER 270 NFWDPSPQLD 280 TQQEIKLCQK 290 SNDISIHHFT 300 CDEENVFAAV 310 GRGLYVYSLQ 320 MKRVIACQKT 330 AHDSNVLHVA 340 RLPNRQLISC 350 SEDGSVRIWE 360 LREKQQLAAE 370 PVPTGFFNMW 380 GFGRVSKQAS 390 QPVKKQQENA 400 TSCSLELIGD 410 LIGHSSSVEM 420 FLYFEDHGLV 430 TCSADHLIIL 440 WKNGERESGL 450 RSLRLFQKLE ENGDLYLAV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0032045	guanyl-nucleotide exchange factor complex
Cellular Component	GO:0005765	lysosomal membrane
Molecular Function	GO:0005096	GTPase activator activity
Biological Process	GO:0006914	autophagy
Biological Process	GO:0045920	negative regulation of exocytosis
Biological Process	GO:0050777	negative regulation of immune response
Biological Process	GO:0010506	regulation of autophagy

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.