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Overview

Uniprot IDQ9HAP2
Protein NameMLX-interacting protein
Gene NameMLXIP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
571 EPVSLVLKNARIAPA

Function

Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation

Protein Sequence

10 MAADVFMCSP 20 RRPRSRGRQV 30 LLKPQVSEDD 40 DDSDTDEPSP 50 PPASGAATPA 60 RAHASAAPPP 70 PRAGPGREEP 80 PRRQQIIHSG 90 HFMVSSPHRE 100 HPPKKGYDFD 110 TVNKQTCQTY 120 SFGKTSSCHL 130 SIDASLTKLF 140 ECMTLAYSGK 150 LVSPKWKNFK 160 GLKLQWRDKI 170 RLNNAIWRAW 180 YMQYLEKRKN 190 PVCHFVTPLD 200 GSVDVDEHRR 210 PEAITTEGKY 220 WKSRIEIVIR 230 EYHKWRTYFK 240 KRLQQHKDED 250 LSSLVQDDDM 260 LYWHKHGDGW 270 KTPVPMEEDP 280 LLDTDMLMSE 290 FSDTLFSTLS 300 SHQPVAWPNP 310 REIAHLGNAD 320 MIQPGLIPLQ 330 PNLDFMDTFE 340 PFQDLFSSSR 350 SIFGSMLPAS 360 ASAPVPDPNN 370 PPAQESILPT 380 TALPTVSLPD 390 SLIAPPTAPS 400 LAHMDEQGCE 410 HTSRTEDPFI 420 QPTDFGPSEP 430 PLSVPQPFLP 440 VFTMPLLSPS 450 PAPPPISPVL 460 PLVPPPATAL 470 NPPAPPTFHQ 480 PQKFAGVNKA 490 PSVITHTASA 500 TLTHDAPATT 510 FSQSQGLVIT 520 THHPAPSAAP 530 CGLALSPVTR 540 PPQPRLTFVH 550 PKPVSLTGGR 560 PKQPHKIVPA 570 PKPEPVSLVL 580 KNARIAPAAF 590 SGQPQAVIMT 600 SGPLKREGML 610 ASTVSQSNVV 620 IAPAAIARAP 630 GVPEFHSSIL 640 VTDLGHGTSS 650 PPAPVSRLFP 660 STAQDPLGKG 670 EQVPLHGGSP 680 QVTVTGPSRD 690 CPNSGQASPC 700 ASEQSPSPQS 710 PQNNCSGKSD 720 PKNVAALKNR 730 QMKHISAEQK 740 RRFNIKMCFD 750 MLNSLISNNS 760 KLTSHAITLQ 770 KTVEYITKLQ 780 QERGQMQEEA 790 RRLREEIEEL 800 NATIISCQQL 810 LPATGVPVTR 820 RQFDHMKDMF 830 DEYVKTRTLQ 840 NWKFWIFSII 850 IKPLFESFKG 860 MVSTSSLEEL 870 HRTALSWLDQ 880 HCSLPILRPM 890 VLSTLRQLST 900 STSILTDPAQ 910 LPEQASKAVT RIGKRLGES

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0046983 protein dimerization activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

PMID: N/A