Overview
| Uniprot ID | Q9HAP6 |
|---|
| Protein Name | Protein lin-7 homolog B |
|---|
| Gene Name | LIN7B |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 98 |
PRVVELPKTDEGLGF |
Function
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity)
Protein Sequence
10
MAALVEPLGL
20
ERDVSRAVEL
30
LERLQRSGEL
40
PPQKLQALQR
50
VLQSRFCSAI
60
REVYEQLYDT
70
LDITGSAEIR
80
AHATAKATVA
90
AFTASEGHAH
100
PRVVELPKTD
110
EGLGFNIMGG
120
KEQNSPIYIS
130
RVIPGGVADR
140
HGGLKRGDQL
150
LSVNGVSVEG
160
EQHEKAVELL
170
KAAQGSVKLV
180
VRYTPRVLEE
190
MEARFEKMRS
200
ARRRQQHQSY
SSLESRG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0005923 |
bicellular tight junction |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0097025 |
MPP7-DLG1-LIN7 complex |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098839 |
postsynaptic density membrane |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0019904 |
protein domain specific binding |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Biological Process |
GO:0006887 |
exocytosis |
| Biological Process |
GO:0007269 |
neurotransmitter secretion |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0008582 |
regulation of synaptic assembly at neuromuscular junction |
| Biological Process |
GO:0048489 |
synaptic vesicle transport |
Reference
PMID: N/A