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Overview

Uniprot IDQ9HAU5
Protein NameRegulator of nonsense transcripts 2
Gene NameUPF2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1266 PNADLIFKTGGRRR*

Function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA

Protein Sequence

10 MPAERKKPAS 20 MEEKDSLPNN 30 KEKDCSERRT 40 VSSKERPKDD 50 IKLTAKKEVS 60 KAPEDKKKRL 70 EDDKRKKEDK 80 ERKKKDEEKV 90 KAEEESKKKE 100 EEEKKKHQEE 110 ERKKQEEQAK 120 RQQEEEAAAQ 130 MKEKEESIQL 140 HQEAWERHHL 150 RKELRSKNQN 160 APDSRPEENF 170 FSRLDSSLKK 180 NTAFVKKLKT 190 ITEQQRDSLS 200 HDFNGLNLSK 210 YIAEAVASIV 220 EAKLKISDVN 230 CAVHLCSLFH 240 QRYADFAPSL 250 LQVWKKHFEA 260 RKEEKTPNIT 270 KLRTDLRFIA 280 ELTIVGIFTD 290 KEGLSLIYEQ 300 LKNIINADRE 310 SHTHVSVVIS 320 FCRHCGDDIA 330 GLVPRKVKSA 340 AEKFNLSFPP 350 SEIISPEKQQ 360 PFQNLLKEYF 370 TSLTKHLKRD 380 HRELQNTERQ 390 NRRILHSKGE 400 LSEDRHKQYE 410 EFAMSYQKLL 420 ANSQSLADLL 430 DENMPDLPQD 440 KPTPEEHGPG 450 IDIFTPGKPG 460 EYDLEGGIWE 470 DEDARNFYEN 480 LIDLKAFVPA 490 ILFKDNEKSC 500 QNKESNKDDT 510 KEAKESKENK 520 EVSSPDDLEL 530 ELENLEINDD 540 TLELEGGDEA 550 EDLTKKLLDE 560 QEQEDEEAST 570 GSHLKLIVDA 580 FLQQLPNCVN 590 RDLIDKAAMD 600 FCMNMNTKAN 610 RKKLVRALFI 620 VPRQRLDLLP 630 FYARLVATLH 640 PCMSDVAEDL 650 CSMLRGDFRF 660 HVRKKDQINI 670 ETKNKTVRFI 680 GELTKFKMFT 690 KNDTLHCLKM 700 LLSDFSHHHI 710 EMACTLLETC 720 GRFLFRSPES 730 HLRTSVLLEQ 740 MMRKKQAMHL 750 DARYVTMVEN 760 AYYYCNPPPA 770 EKTVKKKRPP 780 LQEYVRKLLY 790 KDLSKVTTEK 800 VLRQMRKLPW 810 QDQEVKDYVI 820 CCMINIWNVK 830 YNSIHCVANL 840 LAGLVLYQED 850 VGIHVVDGVL 860 EDIRLGMEVN 870 QPKFNQRRIS 880 SAKFLGELYN 890 YRMVESAVIF 900 RTLYSFTSFG 910 VNPDGSPSSL 920 DPPEHLFRIR 930 LVCTILDTCG 940 QYFDRGSSKR 950 KLDCFLVYFQ 960 RYVWWKKSLE 970 VWTKDHPFPI 980 DIDYMISDTL 990 ELLRPKIKLC 1000 NSLEESIRQV 1010 QDLEREFLIK 1020 LGLVNDKDSK 1030 DSMTEGENLE 1040 EDEEEEEGGA 1050 ETEEQSGNES 1060 EVNEPEEEEG 1070 SDNDDDEGEE 1080 EEEENTDYLT 1090 DSNKENETDE 1100 ENTEVMIKGG 1110 GLKHVPCVED 1120 EDFIQALDKM 1130 MLENLQQRSG 1140 ESVKVHQLDV 1150 AIPLHLKSQL 1160 RKGPPLGGGE 1170 GEAESADTMP 1180 FVMLTRKGNK 1190 QQFKILNVPM 1200 SSQLAANHWN 1210 QQQAEQEERM 1220 RMKKLTLDIN 1230 ERQEQEDYQE 1240 MLQSLAQRPA 1250 PANTNRERRP 1260 RYQHPKGAPN 1270 ADLIFKTGGR RR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0035145 exon-exon junction complex
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0042162 telomeric DNA binding
Biological Process GO:0006406 mRNA export from nucleus
Biological Process GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Reference

PMID: N/A