Search Results
Overview
| Uniprot ID | Q9HAV7 |
|---|---|
| Protein Name | GrpE protein homolog 1, mitochondrial |
| Gene Name | GRPEL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 94 | NLRQRSQKLVEEAKL |
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (PubMed:11311562)
Protein Sequence
10
MAAQCVRLAR
20
RSLPALALSL
30
RPSPRLLCTA
40
TKQKNSGQNL
50
EEDMGQSEQK
60
ADPPATEKTL
70
LEEKVKLEEQ
80
LKETVEKYKR
90
ALADTENLRQ
100
RSQKLVEEAK
110
LYGIQAFCKD
120
LLEVADVLEK
130
ATQCVPKEEI
140
KDDNPHLKNL
150
YEGLVMTEVQ
160
IQKVFTKHGL
170
LKLNPVGAKF
180
DPYEHEALFH
190
TPVEGKEPGT
200
VALVSKVGYK
210
LHGRTLRPAL
VGVVKEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0001405 | PAM complex, Tim23 associated import motor |
| Molecular Function | GO:0000774 | adenyl-nucleotide exchange factor activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0030150 | protein import into mitochondrial matrix |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.