Overview
| Uniprot ID | Q9HAW9 |
|---|
| Protein Name | UDP-glucuronosyltransferase 1A8 |
|---|
| Gene Name | UGT1A8 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 431 |
LKAVINDKSYKENIM |
| 434 |
VINDKSYKENIMRLS |
Function
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:16595710, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867, PubMed:21422672). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15472229, PubMed:16595710, PubMed:23288867). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens (PubMed:15472229, PubMed:16595710, PubMed:18719240, PubMed:23288867). Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps (PubMed:16595710). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212)
Protein Sequence
10
MARTGWTSPI
20
PLCVSLLLTC
30
GFAEAGKLLV
40
VPMDGSHWFT
50
MQSVVEKLIL
60
RGHEVVVVMP
70
EVSWQLGKSL
80
NCTVKTYSTS
90
YTLEDLDREF
100
MDFADAQWKA
110
QVRSLFSLFL
120
SSSNGFFNLF
130
FSHCRSLFND
140
RKLVEYLKES
150
SFDAVFLDPF
160
DACGLIVAKY
170
FSLPSVVFAR
180
GIACHYLEEG
190
AQCPAPLSYV
200
PRILLGFSDA
210
MTFKERVRNH
220
IMHLEEHLFC
230
QYFSKNALEI
240
ASEILQTPVT
250
AYDLYSHTSI
260
WLLRTDFVLD
270
YPKPVMPNMI
280
FIGGINCHQG
290
KPLPMEFEAY
300
INASGEHGIV
310
VFSLGSMVSE
320
IPEKKAMAIA
330
DALGKIPQTV
340
LWRYTGTRPS
350
NLANNTILVK
360
WLPQNDLLGH
370
PMTRAFITHA
380
GSHGVYESIC
390
NGVPMVMMPL
400
FGDQMDNAKR
410
METKGAGVTL
420
NVLEMTSEDL
430
ENALKAVIND
440
KSYKENIMRL
450
SSLHKDRPVE
460
PLDLAVFWVE
470
FVMRHKGAPH
480
LRPAAHDLTW
490
YQYHSLDVIG
500
FLLAVVLTVA
510
FITFKCCAYG
520
YRKCLGKKGR
530
VKKAHKSKTH
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0008202 |
steroid metabolic process |
| Biological Process |
GO:0016125 |
sterol metabolic process |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0004857 |
enzyme inhibitor activity |
| Molecular Function |
GO:0005504 |
fatty acid binding |
| Molecular Function |
GO:0015020 |
glucuronosyltransferase activity |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0001972 |
retinoic acid binding |
| Molecular Function |
GO:0005496 |
steroid binding |
| Molecular Function |
GO:0008194 |
UDP-glycosyltransferase activity |
| Biological Process |
GO:0071385 |
cellular response to glucocorticoid stimulus |
| Biological Process |
GO:0009804 |
coumarin metabolic process |
| Biological Process |
GO:0008210 |
estrogen metabolic process |
| Biological Process |
GO:0006631 |
fatty acid metabolic process |
| Biological Process |
GO:0051552 |
flavone metabolic process |
| Biological Process |
GO:0009812 |
flavonoid metabolic process |
| Biological Process |
GO:0001889 |
liver development |
| Biological Process |
GO:0045922 |
negative regulation of fatty acid metabolic process |
| Biological Process |
GO:0045939 |
negative regulation of steroid metabolic process |
| Biological Process |
GO:0042573 |
retinoic acid metabolic process |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.