Search Results

Overview

Uniprot IDQ9HB07
Protein NameMYG1 exonuclease
Gene NameMYG1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
40 PPKRSRSKLMAPPRI

Function

3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable)

Protein Sequence

10 MGHRFLRGLL 20 TLLLPPPPLY 30 TRHRMLGPES 40 VPPPKRSRSK 50 LMAPPRIGTH 60 NGTFHCDEAL 70 ACALLRLLPE 80 YRDAEIVRTR 90 DPEKLASCDI 100 VVDVGGEYDP 110 RRHRYDHHQR 120 SFTETMSSLS 130 PGKPWQTKLS 140 SAGLIYLHFG 150 HKLLAQLLGT 160 SEEDSMVGTL 170 YDKMYENFVE 180 EVDAVDNGIS 190 QWAEGEPRYA 200 LTTTLSARVA 210 RLNPTWNHPD 220 QDTEAGFKRA 230 MDLVQEEFLQ 240 RLDFYQHSWL 250 PARALVEEAL 260 AQRFQVDPSG 270 EIVELAKGAC 280 PWKEHLYHLE 290 SGLSPPVAIF 300 FVIYTDQAGQ 310 WRIQCVPKEP 320 HSFQSRLPLP 330 EPWRGLRDEA 340 LDQVSGIPGC 350 IFVHASGFIG 360 GHRTREGALS 370 MARATLAQRS YLPQIS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000175 3'-5'-RNA exonuclease activity
Biological Process GO:0000959 mitochondrial RNA metabolic process
Biological Process GO:0006397 mRNA processing
Biological Process GO:0006364 rRNA processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.