Search Results
Overview
| Uniprot ID | Q9HBE1 |
|---|---|
| Protein Name | POZ-, AT hook-, and zinc finger-containing protein 1 |
| Gene Name | PATZ1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 272 | RGRGRPRKANLLDSM |
Function
Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552)
Protein Sequence
10
MERVNDASCG
20
PSGCYTYQVS
30
RHSTEMLHNL
40
NQQRKNGGRF
50
CDVLLRVGDE
60
SFPAHRAVLA
70
ACSEYFESVF
80
SAQLGDGGAA
90
DGGPADVGGA
100
TAAPGGGAGG
110
SRELEMHTIS
120
SKVFGDILDF
130
AYTSRIVVRL
140
ESFPELMTAA
150
KFLLMRSVIE
160
ICQEVIKQSN
170
VQILVPPARA
180
DIMLFRPPGT
190
SDLGFPLDMT
200
NGAALAANSN
210
GIAGSMQPEE
220
EAARAAGAAI
230
AGQASLPVLP
240
GVDRLPMVAG
250
PLSPQLLTSP
260
FPSVASSAPP
270
LTGKRGRGRP
280
RKANLLDSMF
290
GSPGGLREAG
300
ILPCGLCGKV
310
FTDANRLRQH
320
EAQHGVTSLQ
330
LGYIDLPPPR
340
LGENGLPISE
350
DPDGPRKRSR
360
TRKQVACEIC
370
GKIFRDVYHL
380
NRHKLSHSGE
390
KPYSCPVCGL
400
RFKRKDRMSY
410
HVRSHDGSVG
420
KPYICQSCGK
430
GFSRPDHLNG
440
HIKQVHTSER
450
PHKCQTCNAS
460
FATRDRLRSH
470
LACHEDKVPC
480
QVCGKYLRAA
490
YMADHLKKHS
500
EGPSNFCSIC
510
NRGFSSASYL
520
KVHVKTHHGV
530
PLPQVSRHQE
540
PILNGGAAFH
550
CARTYGNKEG
560
QKCSHQDPIE
570
SSDSYGDLSD
580
ASDLKTPEKQ
590
SANGSFSCDM
600
AVPKNKMESD
610
GEKKYPCPEC
620
GSFFRSKSYL
630
NKHIQKVHVR
640
ALGGPLGDLG
650
PALGSPFSPQ
660
QNMSLLESFG
670
FQIVQSAFAS
680
SLVDPEVDQQ
PMGPEGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0010596 | negative regulation of endothelial cell migration |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001817 | regulation of cytokine production |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0002682 | regulation of immune system process |
Reference
PMID: N/A