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Overview

Uniprot ID	Q9HBI1
Protein Name	Beta-parvin
Gene Name	PARVB
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
16	TPRPRRMKKDESFLG
17	PRPRRMKKDESFLGK
24	KDESFLGKLGGTLAR

Function

Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration

Protein Sequence

10 MSSAPRSPTP 20 RPRRMKKDES 30 FLGKLGGTLA 40 RKRRAREVSD 50 LQEEGKNAIN 60 SPMSPALVDV 70 HPEDTQLEEN 80 EERTMIDPTS 90 KEDPKFKELV 100 KVLLDWINDV 110 LVEERIIVKQ 120 LEEDLYDGQV 130 LQKLLEKLAG 140 CKLNVAEVTQ 150 SEIGQKQKLQ 160 TVLEAVHDLL 170 RPRGWALRWS 180 VDSIHGKNLV 190 AILHLLVSLA 200 MHFRAPIRLP 210 EHVTVQVVVV 220 RKREGLLHSS 230 HISEELTTTT 240 EMMMGRFERD 250 AFDTLFDHAP 260 DKLSVVKKSL 270 ITFVNKHLNK 280 LNLEVTELET 290 QFADGVYLVL 300 LMGLLEDYFV 310 PLHHFYLTPE 320 SFDQKVHNVS 330 FAFELMLDGG 340 LKKPKARPED 350 VVNLDLKSTL 360 RVLYNLFTKY KNVE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0030018	Z disc
Molecular Function	GO:0003779	actin binding
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0030031	cell projection assembly
Biological Process	GO:0071963	establishment or maintenance of cell polarity regulating cell shape
Biological Process	GO:0030032	lamellipodium assembly
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.