Search Results
Overview
| Uniprot ID | Q9HBK9 |
|---|---|
| Protein Name | Arsenite methyltransferase |
| Gene Name | AS3MT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 22 | TYYGQVLKRSADLQT |
| 327 | LIRPIGEKLPTSGGC |
Function
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed:16407288, PubMed:25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655)
Protein Sequence
10
MAALRDAEIQ
20
KDVQTYYGQV
30
LKRSADLQTN
40
GCVTTARPVP
50
KHIREALQNV
60
HEEVALRYYG
70
CGLVIPEHLE
80
NCWILDLGSG
90
SGRDCYVLSQ
100
LVGEKGHVTG
110
IDMTKGQVEV
120
AEKYLDYHME
130
KYGFQASNVT
140
FIHGYIEKLG
150
EAGIKNESHD
160
IVVSNCVINL
170
VPDKQQVLQE
180
AYRVLKHGGE
190
LYFSDVYTSL
200
ELPEEIRTHK
210
VLWGECLGGA
220
LYWKELAVLA
230
QKIGFCPPRL
240
VTANLITIQN
250
KELERVIGDC
260
RFVSATFRLF
270
KHSKTGPTKR
280
CQVIYNGGIT
290
GHEKELMFDA
300
NFTFKEGEIV
310
EVDEETAAIL
320
KNSRFAQDFL
330
IRPIGEKLPT
340
SGGCSALELK
350
DIITDPFKLA
360
EESDSMKSRC
370
VPDAAGGCCG
TKKSC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0030791 | arsenite methyltransferase activity |
| Biological Process | GO:0018872 | arsonoacetate metabolic process |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0009404 | toxin metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.