Search Results
Overview
| Uniprot ID | Q9HBM1 |
|---|---|
| Protein Name | Kinetochore protein Spc25 |
| Gene Name | SPC25 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 19 | SINEFWNKFKSTDTS |
| 21 | NEFWNKFKSTDTSCQ |
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14699129, PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020)
Protein Sequence
10
MVEDELALFD
20
KSINEFWNKF
30
KSTDTSCQMA
40
GLRDTYKDSI
50
KAFAEKLSVK
60
LKEEERMVEM
70
FLEYQNQISR
80
QNKLIQEKKD
90
NLLKLIAEVK
100
GKKQELEVLT
110
ANIQDLKEEY
120
SRKKETISTA
130
NKANAERLKR
140
LQKSADLYKD
150
RLGLEIRKIY
160
GEKLQFIFTN
170
IDPKNPESPF
180
MFSLHLNEAR
190
DYEVSDSAPH
200
LEGLAEFQEN
210
VRKTNNFSAF
220
LANVRKAFTA
TVYN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0031262 | Ndc80 complex |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000940 | outer kinetochore |
| Biological Process | GO:0008608 | attachment of spindle microtubules to kinetochore |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0007094 | mitotic spindle assembly checkpoint signaling |
| Biological Process | GO:0007052 | mitotic spindle organization |
Reference
PMID: N/A