Search Results

Overview

Uniprot IDQ9HC35
Protein NameEchinoderm microtubule-associated protein-like 4
Gene NameEML4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
104 SAVSIAGKETLSSAA
112 ETLSSAAKSGTEKKK
180 KRPSPAEKSHNSWEN
197 DSRNKLSKIPSTPKL
203 SKIPSTPKLIPKVTK
210 KLIPKVTKTADKHKD
214 KVTKTADKHKDVIIN
216 TKTADKHKDVIINQE
452 RKQGIFGKYEKPKFV
493 TVEPTPGKGPKGVYQ
63 EDHVASVKKSVSSKG
69 VKKSVSSKGQPSPRA
802 LVRSHNRKVIAVADD
92 NGSGANRKPSHTSAV
967 EISKEQAKATLLEDQ

Function

Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526)

Protein Sequence

10 MDGFAGSLDD 20 SISAASTSDV 30 QDRLSALESR 40 VQQQEDEITV 50 LKAALADVLR 60 RLAISEDHVA 70 SVKKSVSSKG 80 QPSPRAVIPM 90 SCITNGSGAN 100 RKPSHTSAVS 110 IAGKETLSSA 120 AKSGTEKKKE 130 KPQGQREKKE 140 ESHSNDQSPQ 150 IRASPSPQPS 160 SQPLQIHRQT 170 PESKNATPTK 180 SIKRPSPAEK 190 SHNSWENSDD 200 SRNKLSKIPS 210 TPKLIPKVTK 220 TADKHKDVII 230 NQEGEYIKMF 240 MRGRPITMFI 250 PSDVDNYDDI 260 RTELPPEKLK 270 LEWAYGYRGK 280 DCRANVYLLP 290 TGKIVYFIAS 300 VVVLFNYEER 310 TQRHYLGHTD 320 CVKCLAIHPD 330 KIRIATGQIA 340 GVDKDGRPLQ 350 PHVRVWDSVT 360 LSTLQIIGLG 370 TFERGVGCLD 380 FSKADSGVHL 390 CIIDDSNEHM 400 LTVWDWQKKA 410 KGAEIKTTNE 420 VVLAVEFHPT 430 DANTIITCGK 440 SHIFFWTWSG 450 NSLTRKQGIF 460 GKYEKPKFVQ 470 CLAFLGNGDV 480 LTGDSGGVML 490 IWSKTTVEPT 500 PGKGPKGVYQ 510 ISKQIKAHDG 520 SVFTLCQMRN 530 GMLLTGGGKD 540 RKIILWDHDL 550 NPEREIEVPD 560 QYGTIRAVAE 570 GKADQFLVGT 580 SRNFILRGTF 590 NDGFQIEVQG 600 HTDELWGLAT 610 HPFKDLLLTC 620 AQDRQVCLWN 630 SMEHRLEWTR 640 LVDEPGHCAD 650 FHPSGTVVAI 660 GTHSGRWFVL 670 DAETRDLVSI 680 HTDGNEQLSV 690 MRYSIDGTFL 700 AVGSHDNFIY 710 LYVVSENGRK 720 YSRYGRCTGH 730 SSYITHLDWS 740 PDNKYIMSNS 750 GDYEILYWDI 760 PNGCKLIRNR 770 SDCKDIDWTT 780 YTCVLGFQVF 790 GVWPEGSDGT 800 DINALVRSHN 810 RKVIAVADDF 820 CKVHLFQYPC 830 SKAKAPSHKY 840 SAHSSHVTNV 850 SFTHNDSHLI 860 STGGKDMSII 870 QWKLVEKLSL 880 PQNETVADTT 890 LTKAPVSSTE 900 SVIQSNTPTP 910 PPSQPLNETA 920 EEESRISSSP 930 TLLENSLEQT 940 VEPSEDHSEE 950 ESEEGSGDLG 960 EPLYEEPCNE 970 ISKEQAKATL 980 LEDQQDPSPS S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0045171 intercellular bridge
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0030496 midbody
Cellular Component GO:0072686 mitotic spindle
Molecular Function GO:0043014 alpha-tubulin binding
Molecular Function GO:0048487 beta-tubulin binding
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0008608 attachment of spindle microtubules to kinetochore
Biological Process GO:0051301 cell division
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0007017 microtubule-based process
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0007080 mitotic metaphase chromosome alignment

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.