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Overview

Uniprot IDQ9HC52
Protein NameChromobox protein homolog 8
Gene NameCBX8
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
198 SPGDSSKKRGPKPRK
205 KRGPKPRKELPDPSQ
227 AGLGEYLKGRKLDDT
230 GEYLKGRKLDDTPSG
295 RAAFLEAKGQGALDP
77 KKRGPKPKTFLLKAQ
82 KPKTFLLKAQAKAKA

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility

Protein Sequence

10 MELSAVGERV 20 FAAEALLKRR 30 IRKGRMEYLV 40 KWKGWSQKYS 50 TWEPEENILD 60 ARLLAAFEER 70 EREMELYGPK 80 KRGPKPKTFL 90 LKAQAKAKAK 100 TYEFRSDSAR 110 GIRIPYPGRS 120 PQDLASTSRA 130 REGLRNMGLS 140 PPASSTSTSS 150 TCRAEAPRDR 160 DRDRDRDRER 170 DRERERERER 180 ERERERERER 190 GTSRVDDKPS 200 SPGDSSKKRG 210 PKPRKELPDP 220 SQRPLGEPSA 230 GLGEYLKGRK 240 LDDTPSGAGK 250 FPAGHSVIQL 260 ARRQDSDLVQ 270 CGVTSPSSAE 280 ATGKLAVDTF 290 PARVIKHRAA 300 FLEAKGQGAL 310 DPNGTRVRHG 320 SGPPSSGGGL 330 YRDMGAQGGR 340 PSLIARIPVA 350 RILGDPEEES 360 WSPSLTNLEK 370 VVVTDVTSNF 380 LTVTIKESNT DQGFFKEKR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0031519 PcG protein complex
Cellular Component GO:0035102 PRC1 complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0061628 histone H3K27me3 reader activity
Molecular Function GO:0003727 single-stranded RNA binding
Molecular Function GO:0097027 ubiquitin-protein transferase activator activity
Biological Process GO:0070301 cellular response to hydrogen peroxide
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0032967 positive regulation of collagen biosynthetic process
Biological Process GO:0045739 positive regulation of DNA repair

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.