Search Results

Overview

Uniprot ID	Q9HCC0
Protein Name	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
Gene Name	MCCC2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
235	DENIIVRKQGTIFLA
269	GADLHCRKSGVSDHW
420	YEAEGIAKDGAKMVA
512	LKEPIIKKFEEEGNP
70	IKLGGGEKARALHIS

Function

Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism

Protein Sequence

10 MWAVLRLALR 20 PCARASPAGP 30 RAYHGDSVAS 40 LGTQPDLGSA 50 LYQENYKQMK 60 ALVNQLHERV 70 EHIKLGGGEK 80 ARALHISRGK 90 LLPRERIDNL 100 IDPGSPFLEL 110 SQFAGYQLYD 120 NEEVPGGGII 130 TGIGRVSGVE 140 CMIIANDATV 150 KGGAYYPVTV 160 KKQLRAQEIA 170 MQNRLPCIYL 180 VDSGGAYLPR 190 QADVFPDRDH 200 FGRTFYNQAI 210 MSSKNIAQIA 220 VVMGSCTAGG 230 AYVPAMADEN 240 IIVRKQGTIF 250 LAGPPLVKAA 260 TGEEVSAEDL 270 GGADLHCRKS 280 GVSDHWALDD 290 HHALHLTRKV 300 VRNLNYQKKL 310 DVTIEPSEEP 320 LFPADELYGI 330 VGANLKRSFD 340 VREVIARIVD 350 GSRFTEFKAF 360 YGDTLVTGFA 370 RIFGYPVGIV 380 GNNGVLFSES 390 AKKGTHFVQL 400 CCQRNIPLLF 410 LQNITGFMVG 420 REYEAEGIAK 430 DGAKMVAAVA 440 CAQVPKITLI 450 IGGSYGAGNY 460 GMCGRAYSPR 470 FLYIWPNARI 480 SVMGGEQAAN 490 VLATITKDQR 500 AREGKQFSSA 510 DEAALKEPII 520 KKFEEEGNPY 530 YSSARVWDDG 540 IIDPADTRLV 550 LGLSFSAALN 560 APIEKTDFGI FRM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:1905202	methylcrotonoyl-CoA carboxylase complex
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004485	methylcrotonoyl-CoA carboxylase activity
Biological Process	GO:0009083	branched-chain amino acid catabolic process
Biological Process	GO:0015936	coenzyme A metabolic process
Biological Process	GO:0006552	L-leucine catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.