Search Results
Overview
| Uniprot ID | Q9HCD5 |
|---|---|
| Protein Name | Nuclear receptor coactivator 5 |
| Gene Name | NCOA5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 140 | MDDYCRRKDDSYFDR |
Function
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2)
Protein Sequence
10
MNTAPSRPSP
20
TRRDPYGFGD
30
SRDSRRDRSP
40
IRGSPRREPR
50
DGRNGRDARD
60
SRDIRDPRDL
70
RDHRHSRDLR
80
DHRDSRSVRD
90
VRDVRDLRDF
100
RDLRDSRDFR
110
DQRDPMYDRY
120
RDMRDSRDPM
130
YRREGSYDRY
140
LRMDDYCRRK
150
DDSYFDRYRD
160
SFDGRGPPGP
170
ESQSRAKERL
180
KREERRREEL
190
YRQYFEEIQR
200
RFDAERPVDC
210
SVIVVNKQTK
220
DYAESVGRKV
230
RDLGMVVDLI
240
FLNTEVSLSQ
250
ALEDVSRGGS
260
PFAIVITQQH
270
QIHRSCTVNI
280
MFGTPQEHRN
290
MPQADAMVLV
300
ARNYERYKNE
310
CREKEREEIA
320
RQAAKMADEA
330
ILQERERGGP
340
EEGVRGGHPP
350
AIQSLINLLA
360
DNRYLTAEET
370
DKIINYLRER
380
KERLMRSSTD
390
SLPGPISRQP
400
LGATSGASLK
410
TQPSSQPLQS
420
GQVLPSATPT
430
PSAPPTSQQE
440
LQAKILSLFN
450
SGTVTANSSS
460
ASPSVAAGNT
470
PNQNFSTAAN
480
SQPQQRSQAS
490
GNQPPSILGQ
500
GGSAQNMGPR
510
PGAPSQGLFG
520
QPSSRLAPAS
530
NMTSQRPVSS
540
TGINFDNPSV
550
QKALDTLIQS
560
GPALSHLVSQ
570
TTAQMGQPQA
PMGSYQRHY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0009966 | regulation of signal transduction |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.