Search Results

Overview

Uniprot ID	Q9HCE1
Protein Name	RNA helicase MOV-10
Gene Name	MOV10
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
816	LLLAPSSKKGKARLS
817	LLAPSSKKGKARLSP

Function

5'-3' RNA helicase (PubMed:24726324). Involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324)

Protein Sequence

10 MPSKFSCRQL 20 REAGQCFESF 30 LVVRGLDMET 40 DRERLRTIYN 50 RDFKISFGTP 60 APGFSSMLYG 70 MKIANLAYVT 80 KTRVRFFRLD 90 RWADVRFPEK 100 RRMKLGSDIS 110 KHHKSLLAKI 120 FYDRAEYLHG 130 KHGVDVEVQG 140 PHEARDGQLL 150 IRLDLNRKEV 160 LTLRLRNGGT 170 QSVTLTHLFP 180 LCRTPQFAFY 190 NEDQELPCPL 200 GPGECYELHV 210 HCKTSFVGYF 220 PATVLWELLG 230 PGESGSEGAG 240 TFYIARFLAA 250 VAHSPLAAQL 260 KPMTPFKRTR 270 ITGNPVVTNR 280 IEEGERPDRA 290 KGYDLELSMA 300 LGTYYPPPRL 310 RQLLPMLLQG 320 TSIFTAPKEI 330 AEIKAQLETA 340 LKWRNYEVKL 350 RLLLHLEELQ 360 MEHDIRHYDL 370 ESVPMTWDPV 380 DQNPRLLTLE 390 VPGVTESRPS 400 VLRGDHLFAL 410 LSSETHQEDP 420 ITYKGFVHKV 430 ELDRVKLSFS 440 MSLLSRFVDG 450 LTFKVNFTFN 460 RQPLRVQHRA 470 LELTGRWLLW 480 PMLFPVAPRD 490 VPLLPSDVKL 500 KLYDRSLESN 510 PEQLQAMRHI 520 VTGTTRPAPY 530 IIFGPPGTGK 540 TVTLVEAIKQ 550 VVKHLPKAHI 560 LACAPSNSGA 570 DLLCQRLRVH 580 LPSSIYRLLA 590 PSRDIRMVPE 600 DIKPCCNWDA 610 KKGEYVFPAK 620 KKLQEYRVLI 630 TTLITAGRLV 640 SAQFPIDHFT 650 HIFIDEAGHC 660 MEPESLVAIA 670 GLMEVKETGD 680 PGGQLVLAGD 690 PRQLGPVLRS 700 PLTQKHGLGY 710 SLLERLLTYN 720 SLYKKGPDGY 730 DPQFITKLLR 740 NYRSHPTILD 750 IPNQLYYEGE 760 LQACADVVDR 770 ERFCRWAGLP 780 RQGFPIIFHG 790 VMGKDEREGN 800 SPSFFNPEEA 810 ATVTSYLKLL 820 LAPSSKKGKA 830 RLSPRSVGVI 840 SPYRKQVEKI 850 RYCITKLDRE 860 LRGLDDIKDL 870 KVGSVEEFQG 880 QERSVILIST 890 VRSSQSFVQL 900 DLDFNLGFLK 910 NPKRFNVAVT 920 RAKALLIIVG 930 NPLLLGHDPD 940 WKVFLEFCKE 950 NGGYTGCPFP 960 AKLDLQQGQN 970 LLQGLSKLSP 980 STSGPHSHDY 990 LPQEREGEGG 1000 LSLQVEPEWR NEL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule
Cellular Component	GO:0010494	cytoplasmic stress granule
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0043186	P granule
Cellular Component	GO:0000932	P-body
Molecular Function	GO:0032574	5'-3' RNA helicase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization
Biological Process	GO:0051607	defense response to virus
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0035279	miRNA-mediated gene silencing by mRNA destabilization
Biological Process	GO:0035195	miRNA-mediated post-transcriptional gene silencing
Biological Process	GO:0061014	positive regulation of mRNA catabolic process
Biological Process	GO:0150011	regulation of neuron projection arborization
Biological Process	GO:0035194	regulatory ncRNA-mediated post-transcriptional gene silencing
Biological Process	GO:0010526	transposable element silencing
Biological Process	GO:0141008	transposable element silencing by mRNA destabilization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.