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Overview

Uniprot IDQ9HCE6
Protein NameRho guanine nucleotide exchange factor 10-like protein
Gene NameARHGEF10L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
255 KAAKSGTKDGLEKTR
268 TRMAVMRKVSFLHRK
528 SDRSSLNKLLTSGQR
724 LLPGKPDKSGRPISF

Function

Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC

Protein Sequence

10 MASSNPPPQP 20 AIGDQLVPGV 30 PGPSSEAEDD 40 PGEAFEFDDS 50 DDEEDTSAAL 60 GVPSLAPERD 70 TDPPLIHLDS 80 IPVTDPDPAA 90 APPGTGVPAW 100 VSNGDAADAA 110 FSGARHSSWK 120 RKSSRRIDRF 130 TFPALEEDVI 140 YDDVPCESPD 150 AHQPGAERNL 160 LYEDAHRAGA 170 PRQAEDLGWS 180 SSEFESYSED 190 SGEEAKPEVE 200 VEPAKHRVSF 210 QPKLSPDLTR 220 LKERYARTKR 230 DILALRVGGR 240 DMQELKHKYD 250 CKMTQLMKAA 260 KSGTKDGLEK 270 TRMAVMRKVS 280 FLHRKDVLGD 290 SEEEDMGLLE 300 VSVSDIKPPA 310 PELGPMPEGL 320 SPQQVVRRHI 330 LGSIVQSEGS 340 YVESLKRILQ 350 DYRNPLMEME 360 PKALSARKCQ 370 VVFFRVKEIL 380 HCHSMFQIAL 390 SSRVAEWDST 400 EKIGDLFVAS 410 FSKSMVLDVY 420 SDYVNNFTSA 430 MSIIKKACLT 440 KPAFLEFLKR 450 RQVCSPDRVT 460 LYGLMVKPIQ 470 RFPQFILLLQ 480 DMLKNTPRGH 490 PDRLSLQLAL 500 TELETLAEKL 510 NEQKRLADQV 520 AEIQQLTKSV 530 SDRSSLNKLL 540 TSGQRQLLLC 550 ETLTETVYGD 560 RGQLIKSKER 570 RVFLLNDMLV 580 CANINFKPAN 590 HRGQLEISSL 600 VPLGPKYVVK 610 WNTALPQVQV 620 VEVGQDGGTY 630 DKDNVLIQHS 640 GAKKASASGQ 650 AQNKVYLGPP 660 RLFQELQDLQ 670 KDLAVVEQIT 680 LLISTLHGTY 690 QNLNMTVAQD 700 WCLALQRLMR 710 VKEEEIHSAN 720 KCRLRLLLPG 730 KPDKSGRPIS 740 FMVVFITPNP 750 LSKISWVNRL 760 HLAKIGLREE 770 NQPGWLCPDE 780 DKKSKAPFWC 790 PILACCIPAF 800 SSRALSLQLG 810 ALVHSPVNCP 820 LLGFSAVSTS 830 LPQGYLWVGG 840 GQEGAGGQVE 850 IFSLNRPSPR 860 TVKSFPLAAP 870 VLCMEYIPEL 880 EEEAESRDES 890 PTVADPSATV 900 HPTICLGLQD 910 GSILLYSSVD 920 TGTQCLVSCR 930 SPGLQPVLCL 940 RHSPFHLLAG 950 LQDGTLAAYP 960 RTSGGVLWDL 970 ESPPVCLTVG 980 PGPVRTLLSL 990 EDAVWASCGP 1000 RVTVLEATTL 1010 QPQQSFEAHQ 1020 DEAVSVTHMV 1030 KAGSGVWMAF 1040 SSGTSIRLFH 1050 TETLEHLQEI 1060 NIATRTTFLL 1070 PGQKHLCVTS 1080 LLICQGLLWV 1090 GTDQGVIVLL 1100 PVPRLEGIPK 1110 ITGKGMVSLN 1120 GHCGPVAFLA 1130 VATSILAPDI 1140 LRSDQEEAEG 1150 PRAEEDKPDG 1160 QAHEPMPDSH 1170 VGRELTRKKG 1180 ILLQYRLRST 1190 AHLPGPLLSM 1200 REPAPADGAA 1210 LEHSEEDGSI 1220 YEMADDPDIW 1230 VRSRPCARDA 1240 HRKEICSVAI 1250 ISGGQGYRNF 1260 GSALGSSGRQ 1270 APCGETDSTL LIWQVPLML

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0051496 positive regulation of stress fiber assembly
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0032933 SREBP signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.