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Overview

Uniprot IDQ9HCE7
Protein NameE3 ubiquitin-protein ligase SMURF1
Gene NameSMURF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
571 RILQHELKPNGRNVP

Function

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as a positive regulator of smoothened signaling pathway by mediating ubiquitination of PTCH1, leading to endocytosis and lysosomal degradation of PTCH1 (By similarity). Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (PubMed:21791611). Plays a role in dendrite formation by melanocytes (PubMed:23999003)

Protein Sequence

10 MSNPGTRRNG 20 SSIKIRLTVL 30 CAKNLAKKDF 40 FRLPDPFAKI 50 VVDGSGQCHS 60 TDTVKNTLDP 70 KWNQHYDLYV 80 GKTDSITISV 90 WNHKKIHKKQ 100 GAGFLGCVRL 110 LSNAISRLKD 120 TGYQRLDLCK 130 LNPSDTDAVR 140 GQIVVSLQTR 150 DRIGTGGSVV 160 DCRGLLENEG 170 TVYEDSGPGR 180 PLSCFMEEPA 190 PYTDSTGAAA 200 GGGNCRFVES 210 PSQDQRLQAQ 220 RLRNPDVRGS 230 LQTPQNRPHG 240 HQSPELPEGY 250 EQRTTVQGQV 260 YFLHTQTGVS 270 TWHDPRIPSP 280 SGTIPGGDAA 290 FLYEFLLQGH 300 TSEPRDLNSV 310 NCDELGPLPP 320 GWEVRSTVSG 330 RIYFVDHNNR 340 TTQFTDPRLH 350 HIMNHQCQLK 360 EPSQPLPLPS 370 EGSLEDEELP 380 AQRYERDLVQ 390 KLKVLRHELS 400 LQQPQAGHCR 410 IEVSREEIFE 420 ESYRQIMKMR 430 PKDLKKRLMV 440 KFRGEEGLDY 450 GGVAREWLYL 460 LCHEMLNPYY 470 GLFQYSTDNI 480 YMLQINPDSS 490 INPDHLSYFH 500 FVGRIMGLAV 510 FHGHYINGGF 520 TVPFYKQLLG 530 KPIQLSDLES 540 VDPELHKSLV 550 WILENDITPV 560 LDHTFCVEHN 570 AFGRILQHEL 580 KPNGRNVPVT 590 EENKKEYVRL 600 YVNWRFMRGI 610 EAQFLALQKG 620 FNELIPQHLL 630 KPFDQKELEL 640 IIGGLDKIDL 650 NDWKSNTRLK 660 HCVADSNIVR 670 WFWQAVETFD 680 EERRARLLQF 690 VTGSTRVPLQ 700 GFKALQGSTG 710 AAGPRLFTIH 720 LIDANTDNLP 730 KAHTCFNRID 740 IPPYESYEKL 750 YEKLLTAVEE TCGFAVE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0070697 activin receptor binding
Molecular Function GO:0070411 I-SMAD binding
Molecular Function GO:0005543 phospholipid binding
Molecular Function GO:0070412 R-SMAD binding
Molecular Function GO:0046332 SMAD binding
Molecular Function GO:0005160 transforming growth factor beta receptor binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0004842 ubiquitin-protein transferase activity
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0030154 cell differentiation
Biological Process GO:0007398 ectoderm development
Biological Process GO:0061736 engulfment of target by autophagosome
Biological Process GO:0032926 negative regulation of activin receptor signaling pathway
Biological Process GO:0030514 negative regulation of BMP signaling pathway
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0045773 positive regulation of axon extension
Biological Process GO:1903861 positive regulation of dendrite extension
Biological Process GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0006611 protein export from nucleus
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0071211 protein targeting to vacuole involved in autophagy
Biological Process GO:0032801 receptor catabolic process
Biological Process GO:0061753 substrate localization to autophagosome
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0060071 Wnt signaling pathway, planar cell polarity pathway

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.