Search Results

Overview

Uniprot IDQ9HCG8
Protein NamePre-mRNA-splicing factor CWC22 homolog
Gene NameCWC22
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
118 DEPATKKKKDELDPL
119 EPATKKKKDELDPLL
2 ******MKSSVAQIK
732 TRSKEVDKLIRNQQT
783 NWRDPITKYTSDKDV
788 ITKYTSDKDVPSERN
841 EKHTHRIKDSENFRR

Function

Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay

Protein Sequence

10 MKSSVAQIKP 20 SSGHDRRENL 30 NSYQRNSSPE 40 DRYEEQERSP 50 RDRDYFDYSR 60 SDYEHSRRGR 70 SYDSSMESRN 80 RDREKRRERE 90 RDTDRKRSRK 100 SPSPGRRNPE 110 TSVTQSSSAQ 120 DEPATKKKKD 130 ELDPLLTRTG 140 GAYIPPAKLR 150 MMQEQITDKN 160 SLAYQRMSWE 170 ALKKSINGLI 180 NKVNISNISI 190 IIQELLQENI 200 VRGRGLLSRS 210 VLQAQSASPI 220 FTHVYAALVA 230 IINSKFPQIG 240 ELILKRLILN 250 FRKGYRRNDK 260 QLCLTASKFV 270 AHLINQNVAH 280 EVLCLEMLTL 290 LLERPTDDSV 300 EVAIGFLKEC 310 GLKLTQVSPR 320 GINAIFERLR 330 NILHESEIDK 340 RVQYMIEVMF 350 AVRKDGFKDH 360 PIILEGLDLV 370 EEDDQFTHML 380 PLEDDYNPED 390 VLNVFKMDPN 400 FMENEEKYKA 410 IKKEILDEGD 420 TDSNTDQDAG 430 SSEEDEEEEE 440 EEGEEDEEGQ 450 KVTIHDKTEI 460 NLVSFRRTIY 470 LAIQSSLDFE 480 ECAHKLLKME 490 FPESQTKELC 500 NMILDCCAQQ 510 RTYEKFFGLL 520 AGRFCMLKKE 530 YMESFEGIFK 540 EQYDTIHRLE 550 TNKLRNVAKM 560 FAHLLYTDSL 570 PWSVLECIKL 580 SEETTTSSSR 590 IFVKIFFQEL 600 CEYMGLPKLN 610 ARLKDETLQP 620 FFEGLLPRDN 630 PRNTRFAINF 640 FTSIGLGGLT 650 DELREHLKNT 660 PKVIVAQKPD 670 VEQNKSSPSS 680 SSSASSSSES 690 DSSDSDSDSS 700 DSSSESSSEE 710 SDSSSISSHS 720 SASANDVRKK 730 GHGKTRSKEV 740 DKLIRNQQTN 750 DRKQKERRQE 760 HGHQETRTER 770 ERRSEKHRDQ 780 NSSGSNWRDP 790 ITKYTSDKDV 800 PSERNNYSRV 810 ANDRDQEMHI 820 DLENKHGDPK 830 KKRGERRNSF 840 SENEKHTHRI 850 KDSENFRRKD 860 RSKSKEMNRK 870 HSGSRSDEDR 880 YQNGAERRWE 890 KSSRYSEQSR 900 ESKKNQDRRR EKSPAKQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005681 spliceosomal complex
Cellular Component GO:0071006 U2-type catalytic step 1 spliceosome
Cellular Component GO:0071007 U2-type catalytic step 2 spliceosome
Cellular Component GO:0071005 U2-type precatalytic spliceosome
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0048024 regulation of mRNA splicing, via spliceosome

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.