Search Results
Overview
| Uniprot ID | Q9HCK5 |
|---|---|
| Protein Name | Protein argonaute-4 |
| Gene Name | AGO4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 305 | VAQYFKQKYSLQLKY |
Function
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV)
Protein Sequence
10
MEALGPGPPA
20
SLFQPPRRPG
30
LGTVGKPIRL
40
LANHFQVQIP
50
KIDVYHYDVD
60
IKPEKRPRRV
70
NREVVDTMVR
80
HFKMQIFGDR
90
QPGYDGKRNM
100
YTAHPLPIGR
110
DRVDMEVTLP
120
GEGKDQTFKV
130
SVQWVSVVSL
140
QLLLEALAGH
150
LNEVPDDSVQ
160
ALDVITRHLP
170
SMRYTPVGRS
180
FFSPPEGYYH
190
PLGGGREVWF
200
GFHQSVRPAM
210
WNMMLNIDVS
220
ATAFYRAQPI
230
IEFMCEVLDI
240
QNINEQTKPL
250
TDSQRVKFTK
260
EIRGLKVEVT
270
HCGQMKRKYR
280
VCNVTRRPAS
290
HQTFPLQLEN
300
GQAMECTVAQ
310
YFKQKYSLQL
320
KYPHLPCLQV
330
GQEQKHTYLP
340
LEVCNIVAGQ
350
RCIKKLTDNQ
360
TSTMIKATAR
370
SAPDRQEEIS
380
RLVKSNSMVG
390
GPDPYLKEFG
400
IVVHNEMTEL
410
TGRVLPAPML
420
QYGGRNKTVA
430
TPNQGVWDMR
440
GKQFYAGIEI
450
KVWAVACFAP
460
QKQCREDLLK
470
SFTDQLRKIS
480
KDAGMPIQGQ
490
PCFCKYAQGA
500
DSVEPMFKHL
510
KMTYVGLQLI
520
VVILPGKTPV
530
YAEVKRVGDT
540
LLGMATQCVQ
550
VKNVVKTSPQ
560
TLSNLCLKIN
570
AKLGGINNVL
580
VPHQRPSVFQ
590
QPVIFLGADV
600
THPPAGDGKK
610
PSIAAVVGSM
620
DGHPSRYCAT
630
VRVQTSRQEI
640
SQELLYSQEV
650
IQDLTNMVRE
660
LLIQFYKSTR
670
FKPTRIIYYR
680
GGVSEGQMKQ
690
VAWPELIAIR
700
KACISLEEDY
710
RPGITYIVVQ
720
KRHHTRLFCA
730
DKTERVGKSG
740
NVPAGTTVDS
750
TITHPSEFDF
760
YLCSHAGIQG
770
TSRPSHYQVL
780
WDDNCFTADE
790
LQLLTYQLCH
800
TYVRCTRSVS
810
IPAPAYYARL
820
VAFRARYHLV
830
DKDHDSAEGS
840
HVSGQSNGRD
850
PQALAKAVQI
860
HHDTQHTMYF
A
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000932 | P-body |
| Cellular Component | GO:0016442 | RISC complex |
| Cellular Component | GO:0070578 | RISC-loading complex |
| Molecular Function | GO:0003725 | double-stranded RNA binding |
| Molecular Function | GO:0035198 | miRNA binding |
| Molecular Function | GO:0004521 | RNA endonuclease activity |
| Molecular Function | GO:0003727 | single-stranded RNA binding |
| Biological Process | GO:0035196 | miRNA processing |
| Biological Process | GO:0035278 | miRNA-mediated gene silencing by inhibition of translation |
| Biological Process | GO:0006402 | mRNA catabolic process |
| Biological Process | GO:0031054 | pre-miRNA processing |
| Biological Process | GO:0035194 | regulatory ncRNA-mediated post-transcriptional gene silencing |
| Biological Process | GO:0070922 | RISC complex assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.