Search Results

Overview

Uniprot IDQ9HCM1
Protein NameRetroelement silencing factor 1
Gene NameRESF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1547 VGGKQPDKIWIDKTK

Function

Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells

Protein Sequence

10 MNWNEKPKSA 20 TLPPLYPKSQ 30 PPFLHQSLIN 40 QITTTSQSSF 50 SYPGSNQEAC 60 MYPGNSNPIS 70 QPLLNIQNYP 80 QQISVSDMHN 90 GTVVASHTSV 100 ERITYANVNG 110 PKQLTHNLQM 120 SSGVTQNVWL 130 NSPMRNPVHS 140 HIGATVSHQT 150 DFGANVPNMP 160 ALQSQLITSD 170 TYSMQMQMIP 180 SNSTRLPVAY 190 QGNQGLNQSF 200 SEQQVDWTQQ 210 CISKGLTYPD 220 YRPPPKLYRY 230 SPQSFLPDST 240 IQKQNFIPHT 250 SLQVKNSQLL 260 NSVLTLPSRQ 270 TSAVPSQQYA 280 TQTDKRPPPP 290 PYNCRYGSQP 300 LQSTQHITKH 310 LSMEVPQSRE 320 MLSSEIRTSF 330 QQQWQNPNEN 340 VSTIGNFTNL 350 KVNTNSKQPF 360 NSPIRSSVDG 370 VQTLAQTNEE 380 KIMDSCNPTS 390 NQVLDTSVAK 400 EKLVRDIKTL 410 VEIKQKFSEL 420 ARKIKINKDL 430 LMAAGCIKMT 440 NTSYSEPAQN 450 SKLSLKQTAK 460 IQSGPQITPV 470 MPENAERQTP 480 TVVESAETNK 490 TQCMLNSDIQ 500 EVNCRRFNQV 510 DSVLPNPVYS 520 EKRPMPDSSH 530 DVKVLTSKTS 540 AVEMTQAVLN 550 TQLSSENVTK 560 VEQNSPAVCE 570 TISVPKSMST 580 EEYKSKIQNE 590 NMLLLALLSQ 600 ARKTQKTVLK 610 DANQTIQDSK 620 PDSCEMNPNT 630 QMTGNQLNLK 640 NMETPSTSNV 650 SGRVLDNSFC 660 SGQESSTKGM 670 PAKSDSSCSM 680 EVLATCLSLW 690 KKQPSDTAKE 700 KECDKLRTNT 710 TAVGISKPAN 720 IHVKSPCSVV 730 GNSNSQNKIS 740 NPSQQTALSM 750 VMHNYESSGI 760 NITKGTELQI 770 AVVSPLVLSE 780 VKTLSVKGIT 790 PAVLPETVYP 800 VIKEGSVCSL 810 QNQLAENAKA 820 TAALKVDVSG 830 PVASTATSTK 840 IFPLTQKEKQ 850 NESTNGNSEV 860 TPNVNQGKHN 870 KLESAIHSPM 880 NDQQISQESR 890 NSTVVSSDTL 900 QIDNICSLVE 910 GDTSYNSQIA 920 KIFSSLPLKM 930 VEPQKPSLPN 940 QQGIGSREPE 950 KQLDNTTENK 960 DFGFQKDKPV 970 QCTDVSHKIC 980 DQSKSEPPLE 990 SSFNNLETNR 1000 VILEKSSLEH 1010 ATEKSTANDT 1020 CSSAAIQEDI 1030 YPQEIDASSN 1040 YTPQDPARNE 1050 IHSDKAPVLY 1060 LHDQLSELLK 1070 EFPYGIEAVN 1080 TREGSVGQQT 1090 TYQTSEDQTA 1100 DKTSSDSKDP 1110 ADQIQITILS 1120 SEQMKEIFPE 1130 QDDQPYVVDK 1140 LAEPQKEEPI 1150 TEVVSQCDLQ 1160 APAAGQSRDS 1170 VILDSEKDDI 1180 HCCALGWLSM 1190 VYEGVPQCQC 1200 NSIKNSSSEE 1210 EKQKEQCSPL 1220 DTNSCKQGER 1230 TSDRDVTVVQ 1240 FKSLVNNPKT 1250 PPDGKSHFPE 1260 LQDDSRKDTP 1270 KTKHKSLPRT 1280 EQELVAGQFS 1290 SKCDKLNPLQ 1300 NHKRKKLRFH 1310 EVTFHSSNKM 1320 TASYEQASQE 1330 TRQKKHVTQN 1340 SRPLKTKTAF 1350 LPNKDVYKKH 1360 SSLGQSLSPE 1370 KIKLKLKSVS 1380 FKQKRKLDQG 1390 NVLDMEVKKK 1400 KHDKQEQKGS 1410 VGATFKLGDS 1420 LSNPNERAIV 1430 KEKMVSNTKS 1440 VDTKASSSKF 1450 SRILTPKEYL 1460 QRQKHKEALS 1470 NKASKKICVK 1480 NVPCDSEHMR 1490 PSKLAVQVES 1500 CGKSNEKHSS 1510 GVQTSKESLN 1520 GLTSHGKNLK 1530 IHHSQESKTY 1540 NILRNVKEKV 1550 GGKQPDKIWI 1560 DKTKLDKLTN 1570 ISNEAQFSQM 1580 PPQVKDQKKL 1590 YLNRVGFKCT 1600 ERESISLTKL 1610 ESSPRKLHKD 1620 KRQENKHKTF 1630 LPVKGNTEKS 1640 NMLEFKLCPD 1650 ILLKNTNSVE 1660 ERKDVKPHPR 1670 KEQAPLQVSG 1680 IKSTKEDWLK 1690 FVATKKRTQK 1700 DSQERDNVNS 1710 RLSKRSFSAD 1720 GFEMLQNPVK 1730 DSKEMFQTYK 1740 QMYLEKRSRS LGSSPVK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042393 histone binding
Molecular Function GO:1990226 histone methyltransferase binding
Biological Process GO:0141005 transposable element silencing by heterochromatin formation

Reference

[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.