Search Results
Overview
| Uniprot ID | Q9HCP0 |
|---|---|
| Protein Name | Casein kinase I isoform gamma-1 |
| Gene Name | CSNK1G1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 49 | PNFRVGKKIGCGNFG |
Function
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN
Protein Sequence
10
MDHPSREKDE
20
RQRTTKPMAQ
30
RSAHCSRPSG
40
SSSSSGVLMV
50
GPNFRVGKKI
60
GCGNFGELRL
70
GKNLYTNEYV
80
AIKLEPIKSR
90
APQLHLEYRF
100
YKQLGSAGEG
110
LPQVYYFGPC
120
GKYNAMVLEL
130
LGPSLEDLFD
140
LCDRTFTLKT
150
VLMIAIQLLS
160
RMEYVHSKNL
170
IYRDVKPENF
180
LIGRQGNKKE
190
HVIHIIDFGL
200
AKEYIDPETK
210
KHIPYREHKS
220
LTGTARYMSI
230
NTHLGKEQSR
240
RDDLEALGHM
250
FMYFLRGSLP
260
WQGLKADTLK
270
ERYQKIGDTK
280
RNTPIEALCE
290
NFPEEMATYL
300
RYVRRLDFFE
310
KPDYEYLRTL
320
FTDLFEKKGY
330
TFDYAYDWVG
340
RPIPTPVGSV
350
HVDSGASAIT
360
RESHTHRDRP
370
SQQQPLRNQV
380
VSSTNGELNV
390
DDPTGAHSNA
400
PITAHAEVEV
410
VEEAKCCCFF
420
KRKRKKTAQR
HK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0016055 | Wnt signaling pathway |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.