Search Results

Overview

Uniprot IDQ9HCS7
Protein NamePre-mRNA-splicing factor SYF1
Gene NameXAB2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
794 QPLRAQSKILFVRSD

Function

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804)

Protein Sequence

10 MVVMARLSRP 20 ERPDLVFEEE 30 DLPYEEEIMR 40 NQFSVKCWLR 50 YIEFKQGAPK 60 PRLNQLYERA 70 LKLLPCSYKL 80 WYRYLKARRA 90 QVKHRCVTDP 100 AYEDVNNCHE 110 RAFVFMHKMP 120 RLWLDYCQFL 130 MDQGRVTHTR 140 RTFDRALRAL 150 PITQHSRIWP 160 LYLRFLRSHP 170 LPETAVRGYR 180 RFLKLSPESA 190 EEYIEYLKSS 200 DRLDEAAQRL 210 ATVVNDERFV 220 SKAGKSNYQL 230 WHELCDLISQ 240 NPDKVQSLNV 250 DAIIRGGLTR 260 FTDQLGKLWC 270 SLADYYIRSG 280 HFEKARDVYE 290 EAIRTVMTVR 300 DFTQVFDSYA 310 QFEESMIAAK 320 METASELGRE 330 EEDDVDLELR 340 LARFEQLISR 350 RPLLLNSVLL 360 RQNPHHVHEW 370 HKRVALHQGR 380 PREIINTYTE 390 AVQTVDPFKA 400 TGKPHTLWVA 410 FAKFYEDNGQ 420 LDDARVILEK 430 ATKVNFKQVD 440 DLASVWCQCG 450 ELELRHENYD 460 EALRLLRKAT 470 ALPARRAEYF 480 DGSEPVQNRV 490 YKSLKVWSML 500 ADLEESLGTF 510 QSTKAVYDRI 520 LDLRIATPQI 530 VINYAMFLEE 540 HKYFEESFKA 550 YERGISLFKW 560 PNVSDIWSTY 570 LTKFIARYGG 580 RKLERARDLF 590 EQALDGCPPK 600 YAKTLYLLYA 610 QLEEEWGLAR 620 HAMAVYERAT 630 RAVEPAQQYD 640 MFNIYIKRAA 650 EIYGVTHTRG 660 IYQKAIEVLS 670 DEHAREMCLR 680 FADMECKLGE 690 IDRARAIYSF 700 CSQICDPRTT 710 GAFWQTWKDF 720 EVRHGNEDTI 730 KEMLRIRRSV 740 QATYNTQVNF 750 MASQMLKVSG 760 SATGTVSDLA 770 PGQSGMDDMK 780 LLEQRAEQLA 790 AEAERDQPLR 800 AQSKILFVRS 810 DASREELAEL 820 AQQVNPEEIQ 830 LGEDEDEDEM 840 DLEPNEVRLE 850 QQSVPAAVFG SLKED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0071014 post-mRNA release spliceosomal complex
Cellular Component GO:0000974 Prp19 complex
Cellular Component GO:0071007 U2-type catalytic step 2 spliceosome
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000349 generation of catalytic spliceosome for first transesterification step
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0006283 transcription-coupled nucleotide-excision repair

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.