Search Results

Overview

Uniprot ID	Q9HD15
Protein Name	Steroid receptor RNA activator 1
Gene Name	SRA1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
11	LYVKPGNKERGWNDP
71	GPPPPSSKAPRSPPV

Function

Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis

Protein Sequence

10 MAELYVKPGN 20 KERGWNDPPQ 30 FSYGLQTQAG 40 GPRRSLLTKR 50 VAAPQDGSPR 60 VPASETSPGP 70 PPMGPPPPSS 80 KAPRSPPVGS 90 GPASGVEPTS 100 FPVESEAVME 110 DVLRPLEQAL 120 EDCRGHTRKQ 130 VCDDISRRLA 140 LLQEQWAGGK 150 LSIPVKKRMA 160 LLVQELSSHR 170 WDAADDIHRS 180 LMVDHVTEVS 190 QWMVGVKRLI 200 AEKRSLFSEE 210 AANEEKSAAT 220 AEKNHTIPGF QQAS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0002153	steroid receptor RNA activator RNA binding
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0045662	negative regulation of myoblast differentiation

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.