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Overview

Uniprot IDQ9HD20
Protein NameEndoplasmic reticulum transmembrane helix translocase
Gene NameATP13A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
989 VTTLQMFKILALNAL

Function

Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005)

Protein Sequence

10 MAAAAAVGNA 20 VPCGARPCGV 30 RPDGQPKPGP 40 QPRALLAAGP 50 ALIANGDELV 60 AAVWPYRRLA 70 LLRRLTVLPF 80 AGLLYPAWLG 90 AAAAGCWGWG 100 SSWVQIPEAA 110 LLVLATICLA 120 HALTVLSGHW 130 SVHAHCALTC 140 TPEYDPSKAT 150 FVKVVPTPNN 160 GSTELVALHR 170 NEGEDGLEVL 180 SFEFQKIKYS 190 YDALEKKQFL 200 PVAFPVGNAF 210 SYYQSNRGFQ 220 EDSEIRAAEK 230 KFGSNKAEMV 240 VPDFSELFKE 250 RATAPFFVFQ 260 VFCVGLWCLD 270 EYWYYSVFTL 280 SMLVAFEASL 290 VQQQMRNMSE 300 IRKMGNKPHM 310 IQVYRSRKWR 320 PIASDEIVPG 330 DIVSIGRSPQ 340 ENLVPCDVLL 350 LRGRCIVDEA 360 MLTGESVPQM 370 KEPIEDLSPD 380 RVLDLQADSR 390 LHVIFGGTKV 400 VQHIPPQKAT 410 TGLKPVDSGC 420 VAYVLRTGFN 430 TSQGKLLRTI 440 LFGVKRVTAN 450 NLETFIFILF 460 LLVFAIAAAA 470 YVWIEGTKDP 480 SRNRYKLFLE 490 CTLILTSVVP 500 PELPIELSLA 510 VNTSLIALAK 520 LYMYCTEPFR 530 IPFAGKVEVC 540 CFDKTGTLTS 550 DSLVVRGVAG 560 LRDGKEVTPV 570 SSIPVETHRA 580 LASCHSLMQL 590 DDGTLVGDPL 600 EKAMLTAVDW 610 TLTKDEKVFP 620 RSIKTQGLKI 630 HQRFHFASAL 640 KRMSVLASYE 650 KLGSTDLCYI 660 AAVKGAPETL 670 HSMFSQCPPD 680 YHHIHTEISR 690 EGARVLALGY 700 KELGHLTHQQ 710 AREVKREALE 720 CSLKFVGFIV 730 VSCPLKADSK 740 AVIREIQNAS 750 HRVVMITGDN 760 PLTACHVAQE 770 LHFIEKAHTL 780 ILQPPSEKGR 790 QCEWRSIDGS 800 IVLPLARGSP 810 KALALEYALC 820 LTGDGLAHLQ 830 ATDPQQLLRL 840 IPHVQVFARV 850 APKQKEFVIT 860 SLKELGYVTL 870 MCGDGTNDVG 880 ALKHADVGVA 890 LLANAPERVV 900 ERRRRPRDSP 910 TLSNSGIRAT 920 SRTAKQRSGL 930 PPSEEQPTSQ 940 RDRLSQVLRD 950 LEDESTPIVK 960 LGDASIAAPF 970 TSKLSSIQCI 980 CHVIKQGRCT 990 LVTTLQMFKI 1000 LALNALILAY 1010 SQSVLYLEGV 1020 KFSDFQATLQ 1030 GLLLAGCFLF 1040 ISRSKPLKTL 1050 SRERPLPNIF 1060 NLYTILTVML 1070 QFFVHFLSLV 1080 YLYREAQARS 1090 PEKQEQFVDL 1100 YKEFEPSLVN 1110 STVYIMAMAM 1120 QMATFAINYK 1130 GPPFMESLPE 1140 NKPLVWSLAV 1150 SLLAIIGLLL 1160 GSSPDFNSQF 1170 GLVDIPVEFK 1180 LVIAQVLLLD 1190 FCLALLADRV 1200 LQFFLGTPKL KVPS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Molecular Function GO:0015410 ABC-type manganese transporter activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
Molecular Function GO:0140567 membrane protein dislocase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0015662 P-type ion transporter activity
Biological Process GO:0140569 extraction of mislocalized protein from ER membrane
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0034220 monoatomic ion transmembrane transport
Biological Process GO:0015031 protein transport
Biological Process GO:0055085 transmembrane transport

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.