Overview
| Uniprot ID | Q9HD26 |
|---|
| Protein Name | Golgi-associated PDZ and coiled-coil motif-containing protein |
|---|
| Gene Name | GOPC |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 423 |
KVLQGFNKKAVTDTH |
| 459 |
DLHTLYHKKSY**** |
| 460 |
LHTLYHKKSY***** |
Function
Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915)
Protein Sequence
10
MSAGGPCPAA
20
AGGGPGGASC
30
SVGAPGGVSM
40
FRWLEVLEKE
50
FDKAFVDVDL
60
LLGEIDPDQA
70
DITYEGRQKM
80
TSLSSCFAQL
90
CHKAQSVSQI
100
NHKLEAQLVD
110
LKSELTETQA
120
EKVVLEKEVH
130
DQLLQLHSIQ
140
LQLHAKTGQS
150
ADSGTIKAKL
160
SGPSVEELER
170
ELEANKKEKM
180
KEAQLEAEVK
190
LLRKENEALR
200
RHIAVLQAEV
210
YGARLAAKYL
220
DKELAGRVQQ
230
IQLLGRDMKG
240
PAHDKLWNQL
250
EAEIHLHRHK
260
TVIRACRGRN
270
DLKRPMQAPP
280
GHDQDSLKKS
290
QGVGPIRKVL
300
LLKEDHEGLG
310
ISITGGKEHG
320
VPILISEIHP
330
GQPADRCGGL
340
HVGDAILAVN
350
GVNLRDTKHK
360
EAVTILSQQR
370
GEIEFEVVYV
380
APEVDSDDEN
390
VEYEDESGHR
400
YRLYLDELEG
410
GGNPGASCKD
420
TSGEIKVLQG
430
FNKKAVTDTH
440
ENGDLGTASE
450
TPLDDGASKL
460
DDLHTLYHKK
SY
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0015031 |
protein transport |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0030660 |
Golgi-associated vesicle membrane |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0030140 |
trans-Golgi network transport vesicle |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0140313 |
molecular sequestering activity |
| Molecular Function |
GO:0044325 |
transmembrane transporter binding |
| Biological Process |
GO:0045176 |
apical protein localization |
| Biological Process |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process |
GO:0006893 |
Golgi to plasma membrane transport |
| Biological Process |
GO:0010360 |
negative regulation of anion channel activity |
| Biological Process |
GO:2000009 |
negative regulation of protein localization to cell surface |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.