Overview
| Uniprot ID | Q9HD34 |
|---|
| Protein Name | LYR motif-containing protein 4 |
|---|
| Gene Name | LYRM4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 47 |
FRENKNVKDPVEIQT |
Function
Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:17331979, PubMed:31664822). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 (PubMed:19454487)
Protein Sequence
10
MAASSRAQVL
20
SLYRAMLRES
30
KRFSAYNYRT
40
YAVRRIRDAF
50
RENKNVKDPV
60
EIQTLVNKAK
70
RDLGVIRRQV
80
HIGQLYSTDK
90
LIIENRDMPR
T
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:1990221 |
L-cysteine desulfurase complex |
| Cellular Component |
GO:0099128 |
mitochondrial [2Fe-2S] assembly complex |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0060090 |
molecular adaptor activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0044571 |
[2Fe-2S] cluster assembly |
| Biological Process |
GO:0044572 |
[4Fe-4S] cluster assembly |
| Biological Process |
GO:0016226 |
iron-sulfur cluster assembly |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.