Search Results
Overview
| Uniprot ID | Q9HD40 |
|---|---|
| Protein Name | O-phosphoseryl-tRNA(Sec) selenium transferase |
| Gene Name | SEPSECS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 173 | IWPRIDQKSCFKSMI |
Function
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis
Protein Sequence
10
MNRESFAAGE
20
RLVSPAYVRQ
30
GCEARRSHEH
40
LIRLLLEKGK
50
CPENGWDEST
60
LELFLHELAI
70
MDSNNFLGNC
80
GVGEREGRVA
90
SALVARRHYR
100
FIHGIGRSGD
110
ISAVQPKAAG
120
SSLLNKITNS
130
LVLDIIKLAG
140
VHTVANCFVV
150
PMATGMSLTL
160
CFLTLRHKRP
170
KAKYIIWPRI
180
DQKSCFKSMI
190
TAGFEPVVIE
200
NVLEGDELRT
210
DLKAVEAKVQ
220
ELGPDCILCI
230
HSTTSCFAPR
240
VPDRLEELAV
250
ICANYDIPHI
260
VNNAYGVQSS
270
KCMHLIQQGA
280
RVGRIDAFVQ
290
SLDKNFMVPV
300
GGAIIAGFND
310
SFIQEISKMY
320
PGRASASPSL
330
DVLITLLSLG
340
SNGYKKLLKE
350
RKEMFSYLSN
360
QIKKLSEAYN
370
ERLLHTPHNP
380
ISLAMTLKTL
390
DEHRDKAVTQ
400
LGSMLFTRQV
410
SGARVVPLGS
420
MQTVSGYTFR
430
GFMSHTNNYP
440
CAYLNAASAI
450
GMKMQDVDLF
460
IKRLDRCLKA
470
VRKERSKESD
480
DNYDKTEDVD
490
IEEMALKLDN
500
VLLDTYQDAS
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0098621 | O-phosphoseryl-tRNA(Sec) selenium transferase activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Biological Process | GO:0001717 | conversion of seryl-tRNAsec to selenocys-tRNAsec |
| Biological Process | GO:0016260 | L-selenocysteine biosynthetic process |
| Biological Process | GO:0001514 | selenocysteine incorporation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.