Search Results
Overview
| Uniprot ID | Q9HD42 |
|---|---|
| Protein Name | Charged multivesicular body protein 1a |
| Gene Name | CHMP1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 40 | VKKALLQKNVECARV |
| 83 | VQTAVTMKGVTKNMA |
| 87 | VTMKGVTKNMAQVTK |
Function
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904930 | amphisome membrane |
| Molecular Function | GO:0008237 | metallopeptidase activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0097352 | autophagosome maturation |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0032509 | endosome transport via multivesicular body sorting pathway |
| Biological Process | GO:1904903 | ESCRT III complex disassembly |
| Biological Process | GO:1902774 | late endosome to lysosome transport |
| Biological Process | GO:0045324 | late endosome to vacuole transport |
| Biological Process | GO:0090148 | membrane fission |
| Biological Process | GO:0061952 | midbody abscission |
| Biological Process | GO:0007076 | mitotic chromosome condensation |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0036258 | multivesicular body assembly |
| Biological Process | GO:0071985 | multivesicular body sorting pathway |
| Biological Process | GO:0061763 | multivesicular body-lysosome fusion |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0031468 | nuclear membrane reassembly |
| Biological Process | GO:0006997 | nucleus organization |
| Biological Process | GO:0001778 | plasma membrane repair |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0010824 | regulation of centrosome duplication |
| Biological Process | GO:1901673 | regulation of mitotic spindle assembly |
| Biological Process | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| Biological Process | GO:0051469 | vesicle fusion with vacuole |
| Biological Process | GO:0016192 | vesicle-mediated transport |
| Biological Process | GO:0046761 | viral budding from plasma membrane |
| Biological Process | GO:0039702 | viral budding via host ESCRT complex |
| Cellular Component | GO:0000421 | autophagosome membrane |
| Cellular Component | GO:0000794 | condensed nuclear chromosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0000815 | ESCRT III complex |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005828 | kinetochore microtubule |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005815 | microtubule organizing center |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005771 | multivesicular body |
| Cellular Component | GO:0032585 | multivesicular body membrane |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005643 | nuclear pore |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0042802 | identical protein binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.