Search Results

Overview

Uniprot ID	Q9HD67
Protein Name	Unconventional myosin-X
Gene Name	MYO10
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1210	TFLWFRSKQEALKQG
1728	TAGEVVEKLIRGLAM

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed:27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts

Protein Sequence

10 MDNFFTEGTR 20 VWLRENGQHF 30 PSTVNSCAEG 40 IVVFRTDYGQ 50 VFTYKQSTIT 60 HQKVTAMHPT 70 NEEGVDDMAS 80 LTELHGGSIM 90 YNLFQRYKRN 100 QIYTYIGSIL 110 ASVNPYQPIA 120 GLYEPATMEQ 130 YSRRHLGELP 140 PHIFAIANEC 150 YRCLWKRHDN 160 QCILISGESG 170 AGKTESTKLI 180 LKFLSVISQQ 190 SLELSLKEKT 200 SCVERAILES 210 SPIMEAFGNA 220 KTVYNNNSSR 230 FGKFVQLNIC 240 QKGNIQGGRI 250 VDYLLEKNRV 260 VRQNPGERNY 270 HIFYALLAGL 280 EHEEREEFYL 290 STPENYHYLN 300 QSGCVEDKTI 310 SDQESFREVI 320 TAMDVMQFSK 330 EEVREVSRLL 340 AGILHLGNIE 350 FITAGGAQVS 360 FKTALGRSAE 370 LLGLDPTQLT 380 DALTQRSMFL 390 RGEEILTPLN 400 VQQAVDSRDS 410 LAMALYACCF 420 EWVIKKINSR 430 IKGNEDFKSI 440 GILDIFGFEN 450 FEVNHFEQFN 460 INYANEKLQE 470 YFNKHIFSLE 480 QLEYSREGLV 490 WEDIDWIDNG 500 ECLDLIEKKL 510 GLLALINEES 520 HFPQATDSTL 530 LEKLHSQHAN 540 NHFYVKPRVA 550 VNNFGVKHYA 560 GEVQYDVRGI 570 LEKNRDTFRD 580 DLLNLLRESR 590 FDFIYDLFEH 600 VSSRNNQDTL 610 KCGSKHRRPT 620 VSSQFKDSLH 630 SLMATLSSSN 640 PFFVRCIKPN 650 MQKMPDQFDQ 660 AVVLNQLRYS 670 GMLETVRIRK 680 AGYAVRRPFQ 690 DFYKRYKVLM 700 RNLALPEDVR 710 GKCTSLLQLY 720 DASNSEWQLG 730 KTKVFLRESL 740 EQKLEKRREE 750 EVSHAAMVIR 760 AHVLGFLARK 770 QYRKVLYCVV 780 IIQKNYRAFL 790 LRRRFLHLKK 800 AAIVFQKQLR 810 GQIARRVYRQ 820 LLAEKREQEE 830 KKKQEEEEKK 840 KREEEERERE 850 RERREAELRA 860 QQEEETRKQQ 870 ELEALQKSQK 880 EAELTRELEK 890 QKENKQVEEI 900 LRLEKEIEDL 910 QRMKEQQELS 920 LTEASLQKLQ 930 ERRDQELRRL 940 EEEACRAAQE 950 FLESLNFDEI 960 DECVRNIERS 970 LSVGSEFSSE 980 LAESACEEKP 990 NFNFSQPYPE 1000 EEVDEGFEAD 1010 DDAFKDSPNP 1020 SEHGHSDQRT 1030 SGIRTSDDSS 1040 EEDPYMNDTV 1050 VPTSPSADST 1060 VLLAPSVQDS 1070 GSLHNSSSGE 1080 STYCMPQNAG 1090 DLPSPDGDYD 1100 YDQDDYEDGA 1110 ITSGSSVTFS 1120 NSYGSQWSPD 1130 YRCSVGTYNS 1140 SGAYRFSSEG 1150 AQSSFEDSEE 1160 DFDSRFDTDD 1170 ELSYRRDSVY 1180 SCVTLPYFHS 1190 FLYMKGGLMN 1200 SWKRRWCVLK 1210 DETFLWFRSK 1220 QEALKQGWLH 1230 KKGGGSSTLS 1240 RRNWKKRWFV 1250 LRQSKLMYFE 1260 NDSEEKLKGT 1270 VEVRTAKEII 1280 DNTTKENGID 1290 IIMADRTFHL 1300 IAESPEDASQ 1310 WFSVLSQVHA 1320 STDQEIQEMH 1330 DEQANPQNAV 1340 GTLDVGLIDS 1350 VCASDSPDRP 1360 NSFVIITANR 1370 VLHCNADTPE 1380 EMHHWITLLQ 1390 RSKGDTRVEG 1400 QEFIVRGWLH 1410 KEVKNSPKMS 1420 SLKLKKRWFV 1430 LTHNSLDYYK 1440 SSEKNALKLG 1450 TLVLNSLCSV 1460 VPPDEKIFKE 1470 TGYWNVTVYG 1480 RKHCYRLYTK 1490 LLNEATRWSS 1500 AIQNVTDTKA 1510 PIDTPTQQLI 1520 QDIKENCLNS 1530 DVVEQIYKRN 1540 PILRYTHHPL 1550 HSPLLPLPYG 1560 DINLNLLKDK 1570 GYTTLQDEAI 1580 KIFNSLQQLE 1590 SMSDPIPIIQ 1600 GILQTGHDLR 1610 PLRDELYCQL 1620 IKQTNKVPHP 1630 GSVGNLYSWQ 1640 ILTCLSCTFL 1650 PSRGILKYLK 1660 FHLKRIREQF 1670 PGSEMEKYAL 1680 FTYESLKKTK 1690 CREFVPSRDE 1700 IEALIHRQEM 1710 TSTVYCHGGG 1720 SCKITINSHT 1730 TAGEVVEKLI 1740 RGLAMEDSRN 1750 MFALFEYNGH 1760 VDKAIESRTV 1770 VADVLAKFEK 1780 LAATSEVGDL 1790 PWKFYFKLYC 1800 FLDTDNVPKD 1810 SVEFAFMFEQ 1820 AHEAVIHGHH 1830 PAPEENLQVL 1840 AALRLQYLQG 1850 DYTLHAAIPP 1860 LEEVYSLQRL 1870 KARISQSTKT 1880 FTPCERLEKR 1890 RTSFLEGTLR 1900 RSFRTGSVVR 1910 QKVEEEQMLD 1920 MWIKEEVSSA 1930 RASIIDKWRK 1940 FQGMNQEQAM 1950 AKYMALIKEW 1960 PGYGSTLFDV 1970 ECKEGGFPQE 1980 LWLGVSADAV 1990 SVYKRGEGRP 2000 LEVFQYEHIL 2010 SFGAPLANTY 2020 KIVVDERELL 2030 FETSEVVDVA 2040 KLMKAYISMI 2050 VKKRYSTTRS ASSQGSSR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030175	filopodium
Cellular Component	GO:0031527	filopodium membrane
Cellular Component	GO:0032433	filopodium tip
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0016459	myosin complex
Cellular Component	GO:0043005	neuron projection
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0001726	ruffle
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0000146	microfilament motor activity
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
Molecular Function	GO:0060002	plus-end directed microfilament motor activity
Molecular Function	GO:0030507	spectrin binding
Biological Process	GO:0030705	cytoskeleton-dependent intracellular transport
Biological Process	GO:0008360	regulation of cell shape
Biological Process	GO:0051489	regulation of filopodium assembly
Biological Process	GO:0007165	signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.