Search Results
Overview
| Uniprot ID | Q9HDC5 |
|---|---|
| Protein Name | Junctophilin-1 |
| Gene Name | JPH1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 517 | VNKPLMSKAPTKEAG |
| 521 | LMSKAPTKEAGAVVP |
| 531 | GAVVPQSKYSGRHHI |
Function
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes
Protein Sequence
10
MTGGRFDFDD
20
GGTYCGGWEE
30
GKAHGHGICT
40
GPKGQGEYSG
50
SWSHGFEVVG
60
GYTWPSGNTY
70
QGYWAQGKRH
80
GLGVETKGKW
90
MYRGEWSHGF
100
KGRYGVRQSL
110
CTPARYEGTW
120
SNGLQDGYGV
130
ETYGDGGTYQ
140
GQWAGGMRHG
150
YGVRQSVPYG
160
MATVIRSPLR
170
TSLASLRSEQ
180
SNGSVLHDAA
190
AAADSPAGTR
200
GGFVLNFHAD
210
AELAGKKKGG
220
LFRRGSLLGS
230
MKLRKSESKS
240
SISSKRSSVR
250
SDAAMSRISS
260
SDANSTISFG
270
DVDCDFCPVE
280
DHVDATTTET
290
YMGEWKNDKR
300
NGFGVSERSN
310
GMKYEGEWAN
320
NKRHGYGCTV
330
FPDGSKEEGK
340
YKNNILVRGI
350
RKQLIPIRHT
360
KTREKVDRAI
370
EGAQRAAAMA
380
RTKVEIANSR
390
TAHARAKADA
400
ADQAALAARQ
410
ECDIARAVAR
420
ELSPDFYQPG
430
PDYVKQRFQE
440
GVDAKENPEE
450
KVPEKPPTPK
460
ESPHFYRKGT
470
TPPRSPEASP
480
KHSHSPASSP
490
KPLKKQNPSS
500
GARLNQDKRS
510
VADEQVTAIV
520
NKPLMSKAPT
530
KEAGAVVPQS
540
KYSGRHHIPN
550
PSNGELHSQY
560
HGYYVKLNAP
570
QHPPVDVEDG
580
DGSSQSSSAL
590
VHKPSANKWS
600
PSKSVTKPVA
610
KESKAEPKAK
620
KSELAIPKNP
630
ASNDSCPALE
640
KEANSGPNSI
650
MIVLVMLLNI
660
GLAILFVHFL
T
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0030314 | junctional membrane complex |
| Cellular Component | GO:0014701 | junctional sarcoplasmic reticulum membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0008307 | structural constituent of muscle |
| Biological Process | GO:0060402 | calcium ion transport into cytosol |
| Biological Process | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling |
| Biological Process | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
Reference
PMID: N/A